中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2010年
1期
28-30
,共3页
朱凤艳%石夏明%张建新%魏立和%张喜梅%吉中孚%张向阳
硃鳳豔%石夏明%張建新%魏立和%張喜梅%吉中孚%張嚮暘
주봉염%석하명%장건신%위립화%장희매%길중부%장향양
褪黑激素%精神分裂症%运动障碍,药物性%自由基
褪黑激素%精神分裂癥%運動障礙,藥物性%自由基
퇴흑격소%정신분렬증%운동장애,약물성%자유기
Melatonin%Schizophrenia%Dyskinesia,drug induced%Free radicals
目的 观察褪黑素治疗慢性精神分裂症患者迟发性运动障碍(TD)的临床疗效和不良反应.方法 选择76例有迟发性运动障碍的精神分裂症住院患者,按照入组顺序用随机数字表将患者分为褪黑素治疗组(以下简称褪黑素组,39例)和对照组(37例).褪黑素组患者每晚服用褪黑素1次(9 mg/次),对照组患者只维持常规治疗;观察期均为12周.76例患者治疗前和治疗第4,8,12周末盲法采用异常不自主运动量表(AIMS)评定TD疗效,采用治疗中需处理的不良反应症状量表(TESS)评定不良反应.结果 治疗第4,8,12周末,对照组患者AIMS总分较治疗前的差异均无统计学意义(配对t检验,P均>0.05);褪黑素组患者AIMS总分均较治疗前显著降低,差异有统计学意义(配对t检验,P均<0.05),治疗第12周末舌部、上肢的TD症状较治疗前显著降低,差异均有统计学意义(配对t检验,P均<0.05).治疗第8,12周末两组AIMS总分差异有统计学意义(t检验,P<0.05).褪黑素组和对照组治疗各时点TESS总分与治疗前比较,褪黑素组患者治疗第4,8,12周末较治疗前均显著降低,差异均有统计学意义(配对t检验,P均<0.05);而对照组及两组间的差异均无统计学意义(t检验,P均>0.05).结论 褪黑素治疗慢性精神分裂症患者TD有效,对舌和上肢的症状效果明显,无不良反应.
目的 觀察褪黑素治療慢性精神分裂癥患者遲髮性運動障礙(TD)的臨床療效和不良反應.方法 選擇76例有遲髮性運動障礙的精神分裂癥住院患者,按照入組順序用隨機數字錶將患者分為褪黑素治療組(以下簡稱褪黑素組,39例)和對照組(37例).褪黑素組患者每晚服用褪黑素1次(9 mg/次),對照組患者隻維持常規治療;觀察期均為12週.76例患者治療前和治療第4,8,12週末盲法採用異常不自主運動量錶(AIMS)評定TD療效,採用治療中需處理的不良反應癥狀量錶(TESS)評定不良反應.結果 治療第4,8,12週末,對照組患者AIMS總分較治療前的差異均無統計學意義(配對t檢驗,P均>0.05);褪黑素組患者AIMS總分均較治療前顯著降低,差異有統計學意義(配對t檢驗,P均<0.05),治療第12週末舌部、上肢的TD癥狀較治療前顯著降低,差異均有統計學意義(配對t檢驗,P均<0.05).治療第8,12週末兩組AIMS總分差異有統計學意義(t檢驗,P<0.05).褪黑素組和對照組治療各時點TESS總分與治療前比較,褪黑素組患者治療第4,8,12週末較治療前均顯著降低,差異均有統計學意義(配對t檢驗,P均<0.05);而對照組及兩組間的差異均無統計學意義(t檢驗,P均>0.05).結論 褪黑素治療慢性精神分裂癥患者TD有效,對舌和上肢的癥狀效果明顯,無不良反應.
목적 관찰퇴흑소치료만성정신분렬증환자지발성운동장애(TD)적림상료효화불량반응.방법 선택76례유지발성운동장애적정신분렬증주원환자,안조입조순서용수궤수자표장환자분위퇴흑소치료조(이하간칭퇴흑소조,39례)화대조조(37례).퇴흑소조환자매만복용퇴흑소1차(9 mg/차),대조조환자지유지상규치료;관찰기균위12주.76례환자치료전화치료제4,8,12주말맹법채용이상불자주운동량표(AIMS)평정TD료효,채용치료중수처리적불량반응증상량표(TESS)평정불량반응.결과 치료제4,8,12주말,대조조환자AIMS총분교치료전적차이균무통계학의의(배대t검험,P균>0.05);퇴흑소조환자AIMS총분균교치료전현저강저,차이유통계학의의(배대t검험,P균<0.05),치료제12주말설부、상지적TD증상교치료전현저강저,차이균유통계학의의(배대t검험,P균<0.05).치료제8,12주말량조AIMS총분차이유통계학의의(t검험,P<0.05).퇴흑소조화대조조치료각시점TESS총분여치료전비교,퇴흑소조환자치료제4,8,12주말교치료전균현저강저,차이균유통계학의의(배대t검험,P균<0.05);이대조조급량조간적차이균무통계학의의(t검험,P균>0.05).결론 퇴흑소치료만성정신분렬증환자TD유효,대설화상지적증상효과명현,무불량반응.
Objective To explore the effectiveness and side effects of melatonin in treatment of tardive dyskinesia in chronic schizophrenic inpatients.Methods Seventy-six inpatients who met with the criteria for schizophrenia (CCMD-3) and tardive dyskinesia (TD) [the Abnormal Involuntary Movement Scale (AIMS) score>3] were randomly divided into the melatonin group (n=39) and control group (n = 37).The patients in melatonin group were given melatonin 9 mg once in the evening, and the controls only received route treatment.The efficacy and safety were assessed with the AIMS and Treatment Emergent Symptoms Scale (TESS) before treatment and at the end of 4,8,12 weeks.Results The total AIMS score in melatonin group decreased significantly after 4, 8, 12 week treatment compared with pretreatment (Paired t-test,P <0.05 ).The tongue and upper limbs of TD symptoms decreased significantly after 12 week treatment in the melatonin group ( P<0.05 ).The total AIMS score after 8, 12 week treatment was significantly lower in melatonin group than control group ( P<0.05).There were no significant differences in TESS total score between both groups after 4,8,12 week treatment(P,< 0.05).Conclusions It indicates that melatonin is effective and safe in the treatment of the chronic schizophrenic inpatients with TD,especially for the tongue and upper limb symptoms.
