中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
6期
619-621
,共3页
H型高血压%叶酸%维生素B12%脑白质病变
H型高血壓%葉痠%維生素B12%腦白質病變
H형고혈압%협산%유생소B12%뇌백질병변
H-type hypertension%Folic acid%Vitamin B12%White matter lesion
目的 观察H型高血压患者血浆同型半胱氨酸(Hcy)及血清叶酸、维生素B12和患者脑白质的变化,为临床干预脑白质病变提供参考依据. 方法 选择大连市友谊医院神经内科、心内科自2010年4月至2011年3月收治的高血压患者110例(其中H型高血压组78例,单纯高血压组32例),选择同期健康体检者50例作为对照组,采用放射免疫分析法检测血浆Hcy及血清叶酸、维生素B12的水平,MRI检查并评价脑白质病变的级别. 结果 H型高血压患者m浆Hcy、血清叶酸、维生素B12水平高于单纯高血压组和对照组,差异有统计学意义(P＜0.05)；3组受试者脑白质病变级别的差异有统计学意义(P＜0.05),由平均秩次判断,脑白质病变在H型高血压组表现明显,其次为单纯高m压组、对照组. 结论 H型高血压患者血中叶酸、维生素B12水平下降,脑白质病变损害严重,可能与高Hcy血症有关.
目的 觀察H型高血壓患者血漿同型半胱氨痠(Hcy)及血清葉痠、維生素B12和患者腦白質的變化,為臨床榦預腦白質病變提供參攷依據. 方法 選擇大連市友誼醫院神經內科、心內科自2010年4月至2011年3月收治的高血壓患者110例(其中H型高血壓組78例,單純高血壓組32例),選擇同期健康體檢者50例作為對照組,採用放射免疫分析法檢測血漿Hcy及血清葉痠、維生素B12的水平,MRI檢查併評價腦白質病變的級彆. 結果 H型高血壓患者m漿Hcy、血清葉痠、維生素B12水平高于單純高血壓組和對照組,差異有統計學意義(P＜0.05)；3組受試者腦白質病變級彆的差異有統計學意義(P＜0.05),由平均秩次判斷,腦白質病變在H型高血壓組錶現明顯,其次為單純高m壓組、對照組. 結論 H型高血壓患者血中葉痠、維生素B12水平下降,腦白質病變損害嚴重,可能與高Hcy血癥有關.
목적 관찰H형고혈압환자혈장동형반광안산(Hcy)급혈청협산、유생소B12화환자뇌백질적변화,위림상간예뇌백질병변제공삼고의거. 방법 선택대련시우의의원신경내과、심내과자2010년4월지2011년3월수치적고혈압환자110례(기중H형고혈압조78례,단순고혈압조32례),선택동기건강체검자50례작위대조조,채용방사면역분석법검측혈장Hcy급혈청협산、유생소B12적수평,MRI검사병평개뇌백질병변적급별. 결과 H형고혈압환자m장Hcy、혈청협산、유생소B12수평고우단순고혈압조화대조조,차이유통계학의의(P＜0.05)；3조수시자뇌백질병변급별적차이유통계학의의(P＜0.05),유평균질차판단,뇌백질병변재H형고혈압조표현명현,기차위단순고m압조、대조조. 결론 H형고혈압환자혈중협산、유생소B12수평하강,뇌백질병변손해엄중,가능여고Hcy혈증유관.
Objective To investigate the levels of plasma homocysteine (Hcy),serum folic acid and serum vitamin B12 in patients with H-type hypertension to provide some reference for intervening the white matter lesions. Methods One hundred and ten patients with hypertension (78 with H-type hypertension and 32 with hypertension),admitted to our hospital from April 2010 to March 2011,and other 50 healthy controls were chosen in our study; plasma Hcy level and serum folic acid and vitamin B12 levels were measured by using radioimmunoassay among control group,hypertension group and H-type hypertension group.White matter lesion changes of all patients were evaluated by MRI. Results The plasma Hcy level and serum folic acid and vitamin B12 levels in H-type hypertension group were significantly higher than those in control group and hypertension group (P＜0.05); the degree of white matter lesions was significantly different between each 2 groups (P＜0.05): the patients of H-type hypertension group had the most obvious white matter lesions, following by hypertension group and control group. Conclusion The patients with H-type hypertension have decreased folic acid and vitamin B12 levels and severe white matter lesion changes, which might be correlated with hyperhomocysteinemia.
