CAJ | 학술논문

目的探讨胃癌淋巴组织增生与上皮钙黏蛋白(E-cadherin)表达的关系及其预后意义.方法对86例胃癌及癌旁组织中的淋巴细胞增生程度和引流区肿大淋巴结进行了观察,并采用免疫组织化学SP法检测胃癌组织E-cadherin表达.结果胃癌周边区淋巴细胞浸润程度与引流区淋巴结反应性增生数量呈正比;与淋巴结的癌转移数量呈反比.E-cadherin表达与胃癌的浸润深度有关,T1、T2期与T3、T4期比较差异有统计学意义(P＜0.05).E-cadherin阳性表达与胃癌周边区淋巴细胞浸润程度、引流区淋巴结反应性增生数量呈正相关;与引流区淋巴结癌转移数量呈负相关.结论胃癌E-cadherin过表达与淋巴组织增生程度及淋巴结癌转移显著相关,可作为判断胃癌预后的指标.
목적 탐토위암림파조직증생여상피개점단백(E-cadherin)표체적관계급기예후의의.방법 대86례위암급암방조직중적림파세포증생정도화인류구종대림파결진행료관찰,병채용면역조직화학SP법검측위암조직E-cadherin표체.결과 위암주변구림파세포침윤정도여인류구림파결반응성증생수량정정비;여림파결적암전이수량정반비.E-cadherin표체여위암적침윤심도유관,T1、T2기여T3、T4기비교차이유통계학의의(P＜0.05).E-cadherin양성표체여위암주변구림파세포침윤정도、인류구림파결반응성증생수량정정상관;여인류구림파결암전이수량정부상관.결론 위암E-cadherin과표체여림파조직증생정도급림파결암전이현저상관,가작위판단위암예후적지표.
Objective To study the relationship and prognosis between E-cadherin gene expression and lymphatic hyperplastic reaction in gastric cancer. Methods The degree of lymphocytosis and draining lymph node from 86 cases of gastric cancer were observed and the expression of E-cadherin gene in gastric cancer were detected by SP method of immunohistochemistry (IHC). Results Lymphocyte infiltration degree around gastric cancers was positively related to the reactive hyperplasia of the lymphnodes and was inversely related to lymphatic metastasis. The expression of E-cadherin has relationship with the infiltration degree of stomach carcinoma. To compare with T1/T2 and T3/T4 phases, the result is significantly different (P ＜0.01).Meanwhile, the expression of E-cadherin was positively correlated with tumor-infiltrated lymphocytes and reactive hyperplasia of the lymph nodes, was negatively correlated with lymphatic metastasis in drainage area.Conclusion The over-expression of E-cadherin gene is significantly related to lymphoproliferation and lymph node metastasis. The abnormal expression of E-cadherin can be used as an index to determine prognosis of gastric carcinoma.