CAJ | 학술논문

由色氨酸甲酯和1,1'-二茂铁二羧酸合成了化合物1[Fc-(CO-L-Trp-OMe)2],并对化合物1在固体和溶液中的结构进行了表征.单晶结构表明,该化合物通过2个分子内氢键,形成了规则的手性构象.通过分子间的氢键,形成了二网状结构.对化合物1的乙腈溶液进行了CD谱的测定.结果表明.该化合物在溶液中呈现P螺旋构象.1H NMR谱和FTIR谱也证实了该化合物在固体和溶液状态中都形成了含分子内氢键的构象.
유색안산갑지화1,1'-이무철이최산합성료화합물1[Fc-(CO-L-Trp-OMe)2],병대화합물1재고체화용액중적결구진행료표정.단정결구표명,해화합물통과2개분자내경건,형성료규칙적수성구상.통과분자간적경건,형성료이망상결구.대화합물1적을정용액진행료CD보적측정.결과표명.해화합물재용액중정현P라선구상.1H NMR보화FTIR보야증실료해화합물재고체화용액상태중도형성료함분자내경건적구상.
The disubstituted ferrocenoyl peptide 1 [Fc-(CO-L-Trp-Ome)2] was prepared from ferrocenedicarboxylic acid (Fc(OH)2) and tryptophan methyl ester. The structure of 1 was studied in the solid state and in solution. The single-crystal structure shows that 1 displays a 1,2'-conformation and two intramolecular hydrogen bondings between CO (Trp) and NH (another Trp) of each peptide chain induce the chirality-organized structure. Additional intermole-cular H-bonding in 1 allows the formation of a 2D net. CD spectra were recorded for 1 in MeCN. It clearly shows a P-helical arrangement of the ferrocene moiety. 1H NMR spectroscopy in CDCI3 and FTIR spectroscopy in KBr also conform the ordered, intramolecular hydrogen bonded conformation in both solid and solution states.