CAJ | 학술논문

合成了12个带支链/环链烷氧基乙酸为离去基团的顺铂类配合物,通过元素分析、红外光谱、核磁共振氢谱和质谱对配合物进行了表征.研究了所有化合物对人非小细胞肺癌A549、人肝癌细胞BFL-7402和人乳腺癌细胞MCF-7细胞系的体外抗肿瘤活性.测试结果表明,12个配合物中有5个对人乳腺癌细胞系MCF-7有较好的体外活性.其中化合物2(顺-二(异丙氧基乙酸根)·二氨合铂(Ⅱ))在所有的化合物中显示最高的活性,对所测3个细胞系都是如此.
합성료12개대지련/배련완양기을산위리거기단적순박류배합물,통과원소분석、홍외광보、핵자공진경보화질보대배합물진행료표정.연구료소유화합물대인비소세포폐암A549、인간암세포BFL-7402화인유선암세포MCF-7세포계적체외항종류활성.측시결과표명,12개배합물중유5개대인유선암세포계MCF-7유교호적체외활성.기중화합물2(순-이(이병양기을산근)·이안합박(Ⅱ))재소유적화합물중현시최고적활성,대소측3개세포계도시여차.
Twelve cisplatin-typed platinium complexes containing alkyl-branched alkoxyacetates and cyclic alkoxyacetates as leaving groups were prepared and characterized by elemental analysis,infrared,electro-spray ionization MS and 1H NMR spectroscopy.All compounds were evaluated for their in vitro cytotoxicity against A549human non-small-cell lung cancer,BEL-7402 human hepatocellular carcinoma and MCF-7 human breast cancer cell lines,respectively.5 out of 12 complexes with alkyl-branched alkoxyacetates showed good cytotoxicity against MCF-7 cell line.Complex 2{cis-(diammine)bis(t-huIoxyacecale)platinum(Ⅱ))showed the highest cytotoxicity against all fhe three cell lines.