CAJ | 학술논문

目的:探讨负性协同刺激分子B7-H4在原发性非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其与NSCLC临床病理特征间的关系.方法:选取南通大学第三附属医院胸外科2008年1月至2009年4月手术切除并经病理证实的NSCLC标本52例.免疫组织化学法检测NSCLC组织中B7-H4分子的表达及CD3~+T细胞浸润程度,分析B7-H4表达水平与NSCLC组织中CD3~+T细胞浸润、临床病理特征间的关系.结果:52例NSCLC组织中B7-H4表达阳性率为48.08%(25/52),正常肺组织不表达或较少表达B7-H4,差异具有统计学意义(P<0.05).B7-H4表达水平与NSCLC临床分期和淋巴结转移呈正相关(P<0.05),与CD3~+T淋巴细胞浸润程度呈负相关(P<0.05),与其他临床病理参数无关(P>0.05).结论:负性协同刺激分子B7-H4在NSCLC发病过程中可能起重要的作用,其阳性表达与NSCLC临床分期及淋巴结转移密切相关,B7-H4为NSCLC的诊断及治疗提供参考依据.
목적:탐토부성협동자격분자B7-H4재원발성비소세포폐암(non-small cell lung cancer,NSCLC)조직중적표체급기여NSCLC림상병리특정간적관계.방법:선취남통대학제삼부속의원흉외과2008년1월지2009년4월수술절제병경병리증실적NSCLC표본52례.면역조직화학법검측NSCLC조직중B7-H4분자적표체급CD3~+T세포침윤정도,분석B7-H4표체수평여NSCLC조직중CD3~+T세포침윤、림상병리특정간적관계.결과:52례NSCLC조직중B7-H4표체양성솔위48.08%(25/52),정상폐조직불표체혹교소표체B7-H4,차이구유통계학의의(P<0.05).B7-H4표체수평여NSCLC림상분기화림파결전이정정상관(P<0.05),여CD3~+T림파세포침윤정도정부상관(P<0.05),여기타림상병리삼수무관(P>0.05).결론:부성협동자격분자B7-H4재NSCLC발병과정중가능기중요적작용,기양성표체여NSCLC림상분기급림파결전이밀절상관,B7-H4위NSCLC적진단급치료제공삼고의거.
Objective: To study the expression of negative costimulatroy molecule B7-H4 in non-small cell lung cancer (NSCLC) tissues and its relationship with the clinical features of NSCLC. Methods: Fifty-two NSCLC specimens from pa-tients who were pathologically diagnosed in our hospital during January 2008 to April 2009 were included in the present study. B7-H4 expression and infiltration of CD3~+ T cells in NSCLC tissues were detected by immunohistochemistry. The correlation between B7-H4 expression, CD3~+ T infiltration, and the clinical features of NSCLC was studied. Results: The positive rate of B7-H4 in 52 NSCLC tissues was 48.08% (25/52), and B7-H4 expression in normal lung tissues was neg-ative or low (P <0.05). B7-H4 expression was positively correlated with the clinical tumor stages and lymph node metas-tasis of NSCLC (P < 0.05), and negatively correlated with tumor infiltration of CD3~+ T cells (P < 0.05), but had no re-lationship with clinicopathologie parameters of NSCLC (P > 0.05). Conclusion: Negative costimulatroy molecule B7-H4 may play important roles in the development of NSCLC. Positive expression of BT-H4 is correlated with the clinical tumor stages and lymph node metastasis of NSCLC, which provides a foundation for diagnosis and therapy of NSCLC.