CAJ | 학술논문

目的:研究2型糖尿病患者认知功能变化和血清脑源性神经营养因子(BDNF)水平的关系.方法:2型糖尿病组144例,正常对照120例,调查所有受试的人口学资料和临床资料,并进行重复性成套神经心理状态测验(RBANS),ELISA检测血清脑源性神经营养因子水平.结果:2型糖尿病组和正常对照组相比,在认知标准化总分、言语功能、即刻记忆、延时记忆和注意功能方面明显下降(P<O.01).2型糖尿病患者血清BDNF水平低于正常(P<O.01).这种BDNF的变化与2型糖尿病患者的认知标准化总分、即刻记忆、视觉广度、延时记忆和注意功能下降相关,调整年龄、性别、文化程度等影响因素后,血清BDNF水平与认知标准化总分、延时记忆和注意功能的关联依然显著(校正后P_总=0.039;P_(延时)=0.025;P_(注意)=0.013).结论:2型糖尿病患者存在认知功能损伤,这种认知损伤,尤其是注意和延时记忆功能下降与血清BDNF降低有关.
목적:연구2형당뇨병환자인지공능변화화혈청뇌원성신경영양인자(BDNF)수평적관계.방법:2형당뇨병조144례,정상대조120례,조사소유수시적인구학자료화림상자료,병진행중복성성투신경심리상태측험(RBANS),ELISA검측혈청뇌원성신경영양인자수평.결과:2형당뇨병조화정상대조조상비,재인지표준화총분、언어공능、즉각기억、연시기억화주의공능방면명현하강(P<O.01).2형당뇨병환자혈청BDNF수평저우정상(P<O.01).저충BDNF적변화여2형당뇨병환자적인지표준화총분、즉각기억、시각엄도、연시기억화주의공능하강상관,조정년령、성별、문화정도등영향인소후,혈청BDNF수평여인지표준화총분、연시기억화주의공능적관련의연현저(교정후P_총=0.039;P_(연시)=0.025;P_(주의)=0.013).결론:2형당뇨병환자존재인지공능손상,저충인지손상,우기시주의화연시기억공능하강여혈청BDNF강저유관.
Objective:To explore the association between serum brain-derived neurotrophic factor (BDNF) level and cognitive dysfunction in patients with type 2 diabetes mellitus(T2DM). Method: The 144 patients with known T2DM were compared with 120 age-sex and education matched, non-diabetic controls. Cognitive function was assessed by using the repeatable battery for the assessment of neuropsycholo-gieal status(RBANS)test. Serum BDNF level was tested by ELISA. Result: In the RBANS test, patients differed significantly from healthy controls on the total index scores and four subscales for attention, speech, immediate and delayed memory(P<0.01). Also, a significant decline in serum level of BDNF in T2DM group was observed comparing with the controls(P<0.01). Performances in RBANS test on attention, visuospatial, immediate memory, delayded memory domains and total index scores in T2DM patients were positively correlated with the level of serum BDNF. Multiple regression analysis showed that the differences between two groups on RBANS attention, delayed memory and total score remained significantly even after controlling the factors of age, gender, and education. Conclusion: Persons with T2DM expressed poorer cognitive performance than healthy controls. Serum BDNF level decreased and associated with cognitive decline in patients with T2DM, especially on the domains of attention and delayed memory.