CAJ | 학술논문

目的观察疏风解表方解热和抗炎作用.方法腹腔注射大肠杆菌内毒素(LPS)诱导大鼠发热,观察疏风解表方对发热大鼠的解热作用;腹腔注射冰醋酸诱导小鼠炎性渗出,观察疏风解表方对小鼠炎性渗出缓解作用；耳廓涂抹二甲苯诱导小鼠炎性肿胀,观察疏风解表方对小鼠炎性肿胀缓解作用.结果 ①模型对照组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为(37.14±0.39、40.31±0.34、40.44±0.44、40.24±0.34、40.05±0.44、39.85±0.37)℃:阿司匹林组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为(37.13±0.33、38.74±0.42、38.86±0.33、39.05±0.36、38.74±0.37、38.64±0.24)℃；疏风解表组的基础体温、1h体温、2h体温、4h体温、6h体温、8h体温分别为( 37.03±0.46、39.02±0.49、38.82±0.49、38.63±0.46℃、38.62±0.52、38.42±0.44)℃.阿司匹林组、疏风解表组模型大鼠各时段体温均降低,与模型对照组比较差异均有统计学意义(P均＜0.01).②各组伊文斯蓝OD值:模型对照组(0.221±0.045),阿司匹林组(0.162±0.053),疏风解表(0.176±0.049),阿司匹林、疏风解表方干预结果比较,差异无统计学意义(P＞0.05).③耳片重量:分别为模型对照组( 1.94±0.55)mg、地塞米松组(1.18±0.40) mg、疏风解表组(1.04±0.41 )mg.应用地塞米松、疏风解表方干预后,耳廓肿胀程度明显降低(P均＜0.01).结论疏风解表方具有解热抗炎作用.
목적 관찰소풍해표방해열화항염작용.방법 복강주사대장간균내독소(LPS)유도대서발열,관찰소풍해표방대발열대서적해열작용;복강주사빙작산유도소서염성삼출,관찰소풍해표방대소서염성삼출완해작용；이곽도말이갑분유도소서염성종창,관찰소풍해표방대소서염성종창완해작용.결과 ①모형대조조적기출체온、1h체온、2h체온、4h체온、6h체온、8h체온분별위(37.14±0.39、40.31±0.34、40.44±0.44、40.24±0.34、40.05±0.44、39.85±0.37)℃:아사필림조적기출체온、1h체온、2h체온、4h체온、6h체온、8h체온분별위(37.13±0.33、38.74±0.42、38.86±0.33、39.05±0.36、38.74±0.37、38.64±0.24)℃；소풍해표조적기출체온、1h체온、2h체온、4h체온、6h체온、8h체온분별위( 37.03±0.46、39.02±0.49、38.82±0.49、38.63±0.46℃、38.62±0.52、38.42±0.44)℃.아사필림조、소풍해표조모형대서각시단체온균강저,여모형대조조비교차이균유통계학의의(P균＜0.01).②각조이문사람OD치:모형대조조(0.221±0.045),아사필림조(0.162±0.053),소풍해표(0.176±0.049),아사필림、소풍해표방간예결과비교,차이무통계학의의(P＞0.05).③이편중량:분별위모형대조조( 1.94±0.55)mg、지새미송조(1.18±0.40) mg、소풍해표조(1.04±0.41 )mg.응용지새미송、소풍해표방간예후,이곽종창정도명현강저(P균＜0.01).결론 소풍해표방구유해열항염작용.
Objective To observe the effect of anti-pyretic and anti-inflammatory of Shufeng Jiebiao decoction.Methods Intraperitoneal injection of Lipopolysaccharides (LPS) was made to cause fever in rats and then to observe the anti-pyretic effect of Shufeng Jiebiao decoction.Intraperitoneal injection of glacial acetic acid was made to led inflammatory exudate in rats and then to observe the anti-inflammatory effect of Shufeng Jiebiao decoction.Smearing cylene in auricles was done to cause inflammatory swelling in rats and then to observe the effect of the alleviation of the inflammatory swelling of Shufeng Jiebiao decoction.Results ①The temperature of rats in the group of the aspirin and the Shufeng Jiebiao decoction were become lower at each time.The basic temperature of the model control group was (37.14±0.39) ℃,the temperature in the first hour was (40.31±0.34) ℃,the second hour was (40.44±0.44) ℃,the fourth hour was (40.24±0.34) ℃,the sixth hour was (40.05 ±0.44)℃,and the eighth hour was (39.85 ±0.37)℃.The basic temperature of the aspirin group was (37.13±0.33)℃,the temperature in the first hour was (38.74±0.42)℃,the second hour was (38.86±0.33) ℃,the fourth hour was (39.05±0.36)℃,the sixth hour was (38.74±0.37)℃,and the eighth hour was 38.64±0.24) ℃.The basic temperature of the Shufeng Jiebiao decoction group was (37.03±0.46) ℃,the temperature in the first hour was (39.02±0.49) ℃,the second hour was (38.82±0.49) ℃,the fourth hour was (38.63±0.46)℃,the sixth hour was (38.62±0.52)℃,and the eighth hour was (38.42±0.44)℃.The differences were statistical significance compared with the model control group (P＜0.01),the onset of anti-pyretic of the Shufeng Jiebiao decoction group was slower than the aspirin group,but it had a longer lasting effect.Moreover,the rats' temperature decrease of the Shufeng Jiebiao decoction group in the fourth hour had a statistical significance compared with the aspirin group.(P＜0.05).② After the intevention of aspirin and the Shufeng Jiebiao decoction,the optical density of evans blue:the model control group was (0.221 ±0.045),the aspirin group was (0.162±0.053),the Shufeng Jiebiao decoction group was (0.176±0.049),the permeability of the abdominal capillary of the rats reduced significantly (P＜0.01).The intervention of the aspirin and the Shufeng Jiebiao decoction had almost no difference.③ After the intervention of the dexamethasone and the Shufeng Jiebiao decoction,the weight of the auricals:the model control group was (1.94±0.55)mg,dexamethasone group was (1.18±0.40)mg,Shufeng Jiebiao decoction group was (1.04±0.41)mg,showing the degree of the swelling of auricals decreased obviously (P＜0.01).The intervention of the dexamethasone and the Shufeng Jiebiao decoction had almost no difference.Conclusion Shufeng Jiebiao Decoction had anti-pyretic and anti-inflammatory effects.