CAJ | 학술논문

棘球蚴病是一种常见的寄生虫病,主要分为囊性棘球蚴病(cystic echinococcosis,CE)和泡性棘球蚴病(alveolar echinococcosis,AE),一直沿用外科治疗,但常引起复发,或因手术时囊液外漏,致使包虫扩散种植.近几十年国内外兴起的化学治疗以甲苯咪唑和苯硫咪唑为有效的抗包虫病药物.基于前者肠道吸收较后者差,现几乎为后者所取代.笔者曾研制消包胶囊(xiao-bao capsule),由槟榔、榧子、蛇脱、土鳖虫、露蜂房和穿山甲等6味药组成,每丸含药粉250 nag.消包胶囊在小鼠实验或临床试用中均有较好的疗效,而且毒性低微,无不良反应.近年来,笔者采用中西药联合治疗CE患者,并在治疗前后作B超对比.该文总结了9例肝CE及1例肺CE患者疗效观察,治疗后B超图像显示,包虫囊肿由混合性回声团取代,开始显非均质性,以后变为均质性强回声团,并有多发性斑状钙化形成,达到治愈的目的.
극구유병시일충상견적기생충병,주요분위낭성극구유병(cystic echinococcosis,CE)화포성극구유병(alveolar echinococcosis,AE),일직연용외과치료,단상인기복발,혹인수술시낭액외루,치사포충확산충식.근궤십년국내외흥기적화학치료이갑분미서화분류미서위유효적항포충병약물.기우전자장도흡수교후자차,현궤호위후자소취대.필자증연제소포효낭(xiao-bao capsule),유빈랑、비자、사탈、토별충、로봉방화천산갑등6미약조성,매환함약분250 nag.소포효낭재소서실험혹림상시용중균유교호적료효,이차독성저미,무불량반응.근년래,필자채용중서약연합치료CE환자,병재치료전후작B초대비.해문총결료9례간CE급1례폐CE환자료효관찰,치료후B초도상현시,포충낭종유혼합성회성단취대,개시현비균질성,이후변위균질성강회성단,병유다발성반상개화형성,체도치유적목적.
Echinococcosis is a common parasitic disease, including cystic echinococcosis (CE) and alveolar echinococcosis (AE). Surgical operation has been the main therapeutic method of echinococcosis. But relapse always occurs. Therefore, chemotherapeutic research rose up at home and abroad in the recent decades.Mebendazole (MBZ) and albendazole (ABZ) are the best anti-echinococcal drugs, especially the former was replaced by the latter due to poor intestinal absorption. Self-designed Xiao-bao capsule was comprised of areca,ornphaia, snake slough, ground beetle, honeycomb and gangolin scales. Each capsule contains 250 mg of powder. The results of mice experiment and clinical trial indicated that Xiao-bao capsule exhibited good efficacy with very low toxicity. The clinical observation on 9 cases of liver CE and 1 case of lung CE treated by combined treatment was summarized in this paper, appended with the ultrasonic comparison of pre- and post-treatment. The ultrasonic figures showed that in the beginning mixed echo group turned to heterogenous, later homogeneity became gradually with occasional multiple calcification, indicating a cure stage.