CAJ | 학술논문

目的了解铜绿假单胞菌引起医院感染的特征及耐药情况,为临床治疗提供理论依据.方法常规方法对本院2006年1月至2007年12月住院患者的各种临床标本进行分离培养,细菌鉴定及药敏试验采用全自动微生物鉴定仪VITEK·TWO进行.结果 212株引起医院感染的铜绿假单胞菌主要分布于血症监护科(ICU)占25.5%(54/212),其次神经内科及呼吸科分别为10.8%(23/212)、9.4%(20/212),感染以肺部感染为主.占65.1%(138/212),对临床常用的多种抗菌药物表现交叉耐药,对氨曲南、替卡西林/克拉维酸、头孢哌酮、庆大霉素及妥布霉素的敏感率较低,在60.0%以下;对美诺培南、左氧氟沙星、亚胺培南、环丙沙星的敏感率较高,分别为83.0%、79.2%、76.9%、75.9%.结论引起医院感染的铜绿假单胞菌具有多重耐药性,临床治疗时应根据药敏结果选用抗菌药物.
목적 료해동록가단포균인기의원감염적특정급내약정황,위림상치료제공이론의거.방법 상규방법대본원2006년1월지2007년12월주원환자적각충림상표본진행분리배양,세균감정급약민시험채용전자동미생물감정의VITEK·TWO진행.결과 212주인기의원감염적동록가단포균주요분포우혈증감호과(ICU)점25.5%(54/212),기차신경내과급호흡과분별위10.8%(23/212)、9.4%(20/212),감염이폐부감염위주.점65.1%(138/212),대림상상용적다충항균약물표현교차내약,대안곡남、체잡서림/극랍유산、두포고동、경대매소급타포매소적민감솔교저,재60.0%이하;대미낙배남、좌양불사성、아알배남、배병사성적민감솔교고,분별위83.0%、79.2%、76.9%、75.9%.결론 인기의원감염적동록가단포균구유다중내약성,림상치료시응근거약민결과선용항균약물.
Objective To investigate the distribution and drug-resistance of Pseudomonas aeruginosa (PA) in hospital infection, and to provide the experimental evidence for clinical therapy. Methods The clinical specimens were collected from Jan 2006 to Dec 2007. Identification of the bacteria and Antimicrobial susceptibility test were performed on VITEK·TWO all-automatic microbiology analysis system. Results Lung was the main infected organ of PA. PA showed cross-resistance to multiple antibiotics. Antimicrobial susceptibility test showed that the sensitive rates of PA to Aztreonam, Ticarcillin/Tazobactam, Cefoperazone, Gentamycinand Tobramycin were lower than 60.0％ ; and the sensitive rates to Meraopenem, Levofloxacin, Imipenem, Ciprofloxacin were 83.0％,79.2％,76.9％75.9％respectively. Conclusion PA is muhi-rosistant to most antimicrobial agents. In the treatment of clinical PA infection ,drugs should be selected according to the results of antimicrobial susceptibility test.