CAJ | 학술논문

目的基于脑静息态功能MRI(fMRI)研究重度吸烟依赖者(HS)脑局部一致性(ReHo),探讨HS自我觉醒机制.方法选取30例HS(HS组)和年龄、性别匹配的31名无酒精烟草滥用健康志愿者(对照组)行3.0T静息态fMRI采集,采用统计参数图(SPM)5软件进行数据预处理,Rest软件计算ReHo值,HS组和对照组间ReHo值比较采用两样本t检验,最终获得ReHo值有统计差异的功能图.结果(1)与对照组比较,静息态下HS组ReHo值减低脑区包括两侧楔前叶、额上回、前额叶内侧及右角回、额下回、枕下回、小脑和左额中回等.(2)与对照组比较,静息态下HS组ReHo值增高脑区包括两侧岛叶、海马旁回、顶叶白质、桥脑及左侧顶下小叶、舌回、丘脑、额下眶回、额颞叶白质、小脑等,且呈左侧化趋势.结论 HS静息态脑默认模式网络活动减低；活动增强脑区组成吸烟成瘾静息态网络,并呈左侧化趋势,反映HS自我觉醒机制.
목적 기우뇌정식태공능MRI(fMRI)연구중도흡연의뢰자(HS)뇌국부일치성(ReHo),탐토HS자아각성궤제.방법 선취30례HS(HS조)화년령、성별필배적31명무주정연초람용건강지원자(대조조)행3.0T정식태fMRI채집,채용통계삼수도(SPM)5연건진행수거예처리,Rest연건계산ReHo치,HS조화대조조간ReHo치비교채용량양본t검험,최종획득ReHo치유통계차이적공능도.결과(1)여대조조비교,정식태하HS조ReHo치감저뇌구포괄량측설전협、액상회、전액협내측급우각회、액하회、침하회、소뇌화좌액중회등.(2)여대조조비교,정식태하HS조ReHo치증고뇌구포괄량측도협、해마방회、정협백질、교뇌급좌측정하소협、설회、구뇌、액하광회、액섭협백질、소뇌등,차정좌측화추세.결론 HS정식태뇌묵인모식망락활동감저；활동증강뇌구조성흡연성은정식태망락,병정좌측화추세,반영HS자아각성궤제.
Objective To explore the mechanism of self-awareness in the heavy smokers(HS)by using regional homogeneity(ReHo)combined with resting-state functional MRI(fMRI).Methods Thirty HS and 31 healthy non-smokers(NS)matched for age and sex underwent a 3.0 T resting-state fMRI.The data were post-processed by SPM 5 and then the ReHo values were calculated by REST software.The ReHo values between the two groups were compared by two-sample t-test.The brain map with significant difference of ReHo value was obtained.Results Compared with that in NS group,the regions with decreased ReHo value included the bilateral precuneus,superior frontal gyrus,medial prefrontal cortex,right angular gyrus,inferior frontal gyrus,inferior occipital gyrus,cerebellum,and left middle frontal gyrus in HS group.The regions of increased ReHo value included the bilateral insula,parahippocampal gyrus,white matter of parietal lobe,pons,left inferior parietal lobule,lingual gyrus,thalamus,inferior orbital gyrus,white matter of temporal-frontal lobe,and cerebellum.The difference was more obvious in the left hemisphere.Conclusions In HS,abnormal ReHo on a resting state which reflects network of smoking addiction.This method may be helpful in understanding the mechanism of self-awareness in HS.