中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
5期
24-25
,共2页
慢性%乙型病毒性肝炎%自然YIDD变异%恩替卡韦
慢性%乙型病毒性肝炎%自然YIDD變異%恩替卡韋
만성%을형병독성간염%자연YIDD변이%은체잡위
Chronic%Viral Hepatitis B%Natural YMDD mutation%Entecavir
目的 观察恩替卡韦治疗慢性乙型肝炎病毒YMDD自然变异临床疗效疗效和安全性.方法 选掸YMDD自然变异患者65例,随机分为对照组和治疗组,对照组予拉米夫定100 mg/d口服治疗、治疗组予恩替卡韦1 mg/d口服治疗,疗程48周.结果 对照组患者在前12周AL T和HBV DNA水平下降显著下降,但在24周后有所反弹;B组在第4周时,ALT升高明显,此后呈下降趋势,在治疗48周后ALT水平和HBV DNA水平与A组比较有显著性差异(P<0.05),ALT复常率、HBV DNA转阴率与A组比较具有差异(P<0.05).结论 恩替卡韦治疗慢性乙型病毒YMDD自然变异患者具有良好的疗效和安全性.
目的 觀察恩替卡韋治療慢性乙型肝炎病毒YMDD自然變異臨床療效療效和安全性.方法 選撣YMDD自然變異患者65例,隨機分為對照組和治療組,對照組予拉米伕定100 mg/d口服治療、治療組予恩替卡韋1 mg/d口服治療,療程48週.結果 對照組患者在前12週AL T和HBV DNA水平下降顯著下降,但在24週後有所反彈;B組在第4週時,ALT升高明顯,此後呈下降趨勢,在治療48週後ALT水平和HBV DNA水平與A組比較有顯著性差異(P<0.05),ALT複常率、HBV DNA轉陰率與A組比較具有差異(P<0.05).結論 恩替卡韋治療慢性乙型病毒YMDD自然變異患者具有良好的療效和安全性.
목적 관찰은체잡위치료만성을형간염병독YMDD자연변이림상료효료효화안전성.방법 선탄YMDD자연변이환자65례,수궤분위대조조화치료조,대조조여랍미부정100 mg/d구복치료、치료조여은체잡위1 mg/d구복치료,료정48주.결과 대조조환자재전12주AL T화HBV DNA수평하강현저하강,단재24주후유소반탄;B조재제4주시,ALT승고명현,차후정하강추세,재치료48주후ALT수평화HBV DNA수평여A조비교유현저성차이(P<0.05),ALT복상솔、HBV DNA전음솔여A조비교구유차이(P<0.05).결론 은체잡위치료만성을형병독YMDD자연변이환자구유량호적료효화안전성.
Objective To explore the efficacy and safety of Entecavir effect on the chronic hepatitis pa-tients with hepatitis B virus YMDD mutstionl. Methods The 65 chronic hepatitis B virus YMDD mutationl pa- tients were randomly divided into two groups:The treatment group and the control, The patients in control re-ceived lamivudineat therapy at a dose of 100 mg daily ;however the patients in treatment group received Ente-cavir therapy at a dose of 1 mg daily,and the course of treatment was 48 weeks. Results Duiring the first 12 weeks,the control group's ALT and HBV DNA level decreased,while after the 24th week,it incredsed a little. The treatment group's ALT level incredsed signifietly at 4th week and then it declined from then on. The num-ber of patients in treatment group whose ALT level came down to mormal and HBV DNA level turned into nega-tive in the treatment group were biter than that of group B( P < 0. 05 ) at 48th week. Conclusion Enteeavir is effective and safe for the chronic hepatitis patients with hepatitis B virus YMDD mutationl.
