中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
18期
25-27
,共3页
哮喘%细支气管炎%普查%危险因素%保护因素
哮喘%細支氣管炎%普查%危險因素%保護因素
효천%세지기관염%보사%위험인소%보호인소
Asthma%Bronchiolitis%Mass screening%Risk factors%Protective factors
目的 对毛细支气管炎后患儿发生哮喘的危险因素进行筛查.方法 收集毛细支气管炎患儿220例的临床及随访资料,对性别、治疗方法、免疫接种、特异性体质、喂养方式、哮喘家族史等进行调查统计,筛选毛细支气管炎后发生哮喘的危险因素.结果 单因素分析显示不同性别的毛细支气管炎患儿哮喘发生率比较差异无统计学意义(P＞0.05),按时接种卡介苗、使用大剂量免疫球蛋白治疗的患儿哮喘发生率低于未按时接种卡介苗及未使用大剂量免疫球蛋白治疗者(P＜0.01),有特异性体质、有哮喘家族史的患儿哮喘发生率高于无特异性体质及无哮喘家族史者(P＜0.01),肥胖患儿哮喘发生率高于非肥胖者(P＜0.05),母乳喂养＞4个月患儿哮喘发生率低于非母乳喂养＞4个月者(P＜0.05).多因素回归分析显示有哮喘家族史、肥胖、有特异性体质是毛细支气管炎患儿发生哮喘的危险因素,使用大剂量免疫球蛋白治疗、按时接种卡介苗、母乳喂养＞4个月是毛细支气管炎患儿发生哮喘的保护因素.结论 有哮喘家族史、有特异性体质、肥胖是毛细支气管炎患儿发生哮喘的危险因素,免疫球蛋白治疗及按时接种卡介苗是减少哮喘发生的保护因素,尤其值得应用在有上述危险因素的患儿中.
目的 對毛細支氣管炎後患兒髮生哮喘的危險因素進行篩查.方法 收集毛細支氣管炎患兒220例的臨床及隨訪資料,對性彆、治療方法、免疫接種、特異性體質、餵養方式、哮喘傢族史等進行調查統計,篩選毛細支氣管炎後髮生哮喘的危險因素.結果 單因素分析顯示不同性彆的毛細支氣管炎患兒哮喘髮生率比較差異無統計學意義(P＞0.05),按時接種卡介苗、使用大劑量免疫毬蛋白治療的患兒哮喘髮生率低于未按時接種卡介苗及未使用大劑量免疫毬蛋白治療者(P＜0.01),有特異性體質、有哮喘傢族史的患兒哮喘髮生率高于無特異性體質及無哮喘傢族史者(P＜0.01),肥胖患兒哮喘髮生率高于非肥胖者(P＜0.05),母乳餵養＞4箇月患兒哮喘髮生率低于非母乳餵養＞4箇月者(P＜0.05).多因素迴歸分析顯示有哮喘傢族史、肥胖、有特異性體質是毛細支氣管炎患兒髮生哮喘的危險因素,使用大劑量免疫毬蛋白治療、按時接種卡介苗、母乳餵養＞4箇月是毛細支氣管炎患兒髮生哮喘的保護因素.結論 有哮喘傢族史、有特異性體質、肥胖是毛細支氣管炎患兒髮生哮喘的危險因素,免疫毬蛋白治療及按時接種卡介苗是減少哮喘髮生的保護因素,尤其值得應用在有上述危險因素的患兒中.
목적 대모세지기관염후환인발생효천적위험인소진행사사.방법 수집모세지기관염환인220례적림상급수방자료,대성별、치료방법、면역접충、특이성체질、위양방식、효천가족사등진행조사통계,사선모세지기관염후발생효천적위험인소.결과 단인소분석현시불동성별적모세지기관염환인효천발생솔비교차이무통계학의의(P＞0.05),안시접충잡개묘、사용대제량면역구단백치료적환인효천발생솔저우미안시접충잡개묘급미사용대제량면역구단백치료자(P＜0.01),유특이성체질、유효천가족사적환인효천발생솔고우무특이성체질급무효천가족사자(P＜0.01),비반환인효천발생솔고우비비반자(P＜0.05),모유위양＞4개월환인효천발생솔저우비모유위양＞4개월자(P＜0.05).다인소회귀분석현시유효천가족사、비반、유특이성체질시모세지기관염환인발생효천적위험인소,사용대제량면역구단백치료、안시접충잡개묘、모유위양＞4개월시모세지기관염환인발생효천적보호인소.결론 유효천가족사、유특이성체질、비반시모세지기관염환인발생효천적위험인소,면역구단백치료급안시접충잡개묘시감소효천발생적보호인소,우기치득응용재유상술위험인소적환인중.
Objective To screen the relative risk and protective factors of children patients with asthma after capillary bronchiolitis.Methods The clinical and follow-up data of 220 children patients with capillary bronchiolitis were collected.Sex,treatment method,immunization vaccination,idiosyncrasy,feeding way,family history were investigated and analyzed.The risk factrs of asthma were screened.Results Univariate analysis showed that the incidence of asthma between different genders had no significant difference (P ＞0.05).The asthma incidence in patients with BCG vaccination on time and large-dose immunoglobulin treatment were lower than those in patients without BCG vaccination on time and large-dose immunoglobulin treatnent (P＜ 0.01 ).The asthma incidence in patients with idiosyncrasy,family history was significantly higher than that in patients without idiosyncrasy,family history( P ＜ 0.05 ).The asthma incidence in patients with obesity was higher than that in other children (P ＜ 0.05).The asthma incidence in patients with more than 4 months breast feeding was lower than that in patients with other feeding ways (P ＜ 0.05 ).Multi-factors regression analysis showed that family history,obesity,idiosyncrasy were the risk factors of asthua,and large-dose immunoglobulin treatment,BCG vaccination on time,breast feeding ＞ 4 months were the protective factors.Conclusions Family history,idiosyncrasy,obesity are the risk factors of asthma in children patients with capillary bronchiolitis,and should be focused on olservation.Immunoglobulin treatment and procedural BCG vaccination are the protective factors to reduce the asthma incidence.They are worthy of application especially in children with risk factors.
