CAJ | 학술논문

目的:在兔眼行硅凝胶膜植入后,通过观察眼内压、滤过泡、病理组织检查结果评价硅凝胶膜植入的安全性和有效性.方法:共40只兔随机分为4组,每组10只.每只兔一眼行巩膜瓣下小梁咬切术,术中植入硅凝胶膜,对侧眼单纯行巩膜瓣下小梁咬切术作为对照.术后观察眼内压、滤过泡的变化,并且每只眼行组织病理学检查.结果:植入眼较对照眼低眼压和滤过泡维持时间长,光镜显示植入眼滤过道、咬切口区保持通畅.成纤维细胞增殖的活性与规律,在植入眼和对照眼是相似的.硅凝胶膜不会刺激成纤维细胞增殖的过度表达.结论:硅凝胶膜植入术作为一种新型引流术具有安全、有效、操作简单的优点.
목적:재토안행규응효막식입후,통과관찰안내압、려과포、병리조직검사결과평개규응효막식입적안전성화유효성.방법:공40지토수궤분위4조,매조10지.매지토일안행공막판하소량교절술,술중식입규응효막,대측안단순행공막판하소량교절술작위대조.술후관찰안내압、려과포적변화,병차매지안행조직병이학검사.결과:식입안교대조안저안압화려과포유지시간장,광경현시식입안려과도、교절구구보지통창.성섬유세포증식적활성여규률,재식입안화대조안시상사적.규응효막불회자격성섬유세포증식적과도표체.결론:규응효막식입술작위일충신형인류술구유안전、유효、조작간단적우점.
·AIM: To investigate the efficacy and security of the silicone membrane implant through observing intraocular pressure, filtering blebs and histopathologic results.·METHODS; Forty rabbits were randomly divided into 4 groups. Each group consisted of 10 rabbits. Trabecu-lectomy and silicone membrane implantation were performed in one eye of each rabbit, while the other eye was only performed trabeculectomy as control. The change of intraocular pressure, filtering blebs were observed postoperatively. And each eye had undergone histopathologic examination.·RESULTS:The duration of low intraocular pressure and existence of filtering blebs in implanted eyes was longer than that in controlled eyes. Light microscopy revealed that patent drainage tract and biting site could be seen in silicone membrane implanted eye. The activity and regularity of fibroblast proliferation in implanted eyes and controlled eyes were similar. Excessive expression of fibroblast proliferation was not induced by silicone membrane.·CONCLUSION: Characterized by safety, effectiveness and simplicity, silicone membrane implantation can act as a new drainage surgery.KEYWORDS: silicone membrane; drainage surgery;intraocular pressure