CAJ | 학술논문

采用循环伏安法制备了聚L-苯丙氨酸薄膜修饰玻碳电极,研究了对乙酰氨基酚在该修饰电极上的电化学行为,建立了循环伏安法测定对乙酰氨基酚的新方法.研究发现:在pH 7.0的磷酸盐缓冲溶液中,聚L-苯丙氨修饰电极对对乙酰氨基酚存在灵敏的氧化作用,氧化峰电位负移50 mV.对乙酰氨基酚的浓度在2.0×10~(-5)～2.0×10-4 mol·L~(-1) 和8.0×10~(-7)～2.0×10~(-5) mol·L~(-1)范围内与其峰电流呈良好的线性关系,检出限为5.0×10~(-7) mol·L~(-1).对1.0×10~(-5) mol·L~(-1)对乙酰氨基酚平行测定5次,相对标准偏差为1.6%.该法可用于药品中对乙酰氨基酚的测定,结果满意.
채용순배복안법제비료취L-분병안산박막수식파탄전겁,연구료대을선안기분재해수식전겁상적전화학행위,건립료순배복안법측정대을선안기분적신방법.연구발현:재pH 7.0적린산염완충용액중,취L-분병안수식전겁대대을선안기분존재령민적양화작용,양화봉전위부이50 mV.대을선안기분적농도재2.0×10~(-5)～2.0×10-4 mol·L~(-1) 화8.0×10~(-7)～2.0×10~(-5) mol·L~(-1)범위내여기봉전류정량호적선성관계,검출한위5.0×10~(-7) mol·L~(-1).대1.0×10~(-5) mol·L~(-1)대을선안기분평행측정5차,상대표준편차위1.6%.해법가용우약품중대을선안기분적측정,결과만의.
A poly (L-phenylalanine) modified electrode is prepared by cyclic voltammetry.The electrochemical behavior of acetaminophen on the modified electrode is studied in detail.In phosphate buffer solution (pH 7.0),the modified electrode reveals an excellent electrocatalytic activity for acetaminophen.The oxidation peak potential is reduced by 50 mV compared with that on the bare glass carbon electrode.The oxidation peak current is well proportional to the concentration of ACOP in the range of 2.0×10~(-s)~2.0× 10~(-4) mol/L and 8.0×10~(-7) ~2.0× 10~(-5) mol/L with a detection limit 5.0×10~(-7) mol/L.The relative standard deviation is estimated to be 1.6 % from the parallel determinations of 1.0 × 10~(-6) mol/L acetaminophen for five times.The modified electrode is easy to be prepared with good reproducibility and is applied to the determination of acetaminophen in drug tablets with satisfactory results.