临床儿科杂志
臨床兒科雜誌
림상인과잡지
2009年
11期
1058-1060
,共3页
刘桂英%张晓虹%孙景辉%苏瑛%许冀闽
劉桂英%張曉虹%孫景輝%囌瑛%許冀閩
류계영%장효홍%손경휘%소영%허기민
川崎病%抗β_2糖蛋白1抗体%基质金属蛋白酶9%冠状动脉损伤
川崎病%抗β_2糖蛋白1抗體%基質金屬蛋白酶9%冠狀動脈損傷
천기병%항β_2당단백1항체%기질금속단백매9%관상동맥손상
Kawasaki disease%anti-β_2GP1 antibodies%matrix metalloproteinase-9%coronary artery lesions
目的 观察川崎病急性期患儿血清抗β_2糖蛋白1(β_2GP1)抗体、基质金属蛋白酶9(MMP-9)水平,探讨其与川崎病相关性及临床意义.方法 采用ELISA法检测47例川崎病患儿血清抗β_2GP1抗体、MMP-9水平,应用SPSS11.5软件进行数据分析.30例同期住院、年龄相仿的感染性疾病患儿为发热对照组,均除外心、肝、肾、血液及风湿性疾病.结果 47例川崎病患儿中并发冠状动脉病变者17例.川崎病组和对照组血清中抗β_2GP1抗体水平分别为(7.46±2.13)U/ml和(4.38±0.43)U/ml;MMP-9分别为(886.62 ±92.72)ng/ml和(460±179.59)ng/ml,两组比较差异均有统计学意义(P均<0.05);川崎病组中冠状动脉损伤与冠状动脉正常患儿血清抗β_2GP1抗体分别为(8.83±0.89)U/ml和(6.18±1.42)U/ml,MMP-9分别为(948.62±81.76)ng/ml和(872.00±34.74)ns/ml,两组比较差异均有统计学意义(P均<0.05);川崎病组血清中抗β_2CP1抗体、MMP-9水平呈显著正相关(r=0.665,P<0.05).结论 抗β_2GP1抗体、MMP-9在川崎病急性期尤其伴冠状动脉病变时明显升高,两者在川崎病发生、发展过程中具有协同作用,是川崎病冠状动脉损伤血清学重要指标.
目的 觀察川崎病急性期患兒血清抗β_2糖蛋白1(β_2GP1)抗體、基質金屬蛋白酶9(MMP-9)水平,探討其與川崎病相關性及臨床意義.方法 採用ELISA法檢測47例川崎病患兒血清抗β_2GP1抗體、MMP-9水平,應用SPSS11.5軟件進行數據分析.30例同期住院、年齡相倣的感染性疾病患兒為髮熱對照組,均除外心、肝、腎、血液及風濕性疾病.結果 47例川崎病患兒中併髮冠狀動脈病變者17例.川崎病組和對照組血清中抗β_2GP1抗體水平分彆為(7.46±2.13)U/ml和(4.38±0.43)U/ml;MMP-9分彆為(886.62 ±92.72)ng/ml和(460±179.59)ng/ml,兩組比較差異均有統計學意義(P均<0.05);川崎病組中冠狀動脈損傷與冠狀動脈正常患兒血清抗β_2GP1抗體分彆為(8.83±0.89)U/ml和(6.18±1.42)U/ml,MMP-9分彆為(948.62±81.76)ng/ml和(872.00±34.74)ns/ml,兩組比較差異均有統計學意義(P均<0.05);川崎病組血清中抗β_2CP1抗體、MMP-9水平呈顯著正相關(r=0.665,P<0.05).結論 抗β_2GP1抗體、MMP-9在川崎病急性期尤其伴冠狀動脈病變時明顯升高,兩者在川崎病髮生、髮展過程中具有協同作用,是川崎病冠狀動脈損傷血清學重要指標.
목적 관찰천기병급성기환인혈청항β_2당단백1(β_2GP1)항체、기질금속단백매9(MMP-9)수평,탐토기여천기병상관성급림상의의.방법 채용ELISA법검측47례천기병환인혈청항β_2GP1항체、MMP-9수평,응용SPSS11.5연건진행수거분석.30례동기주원、년령상방적감염성질병환인위발열대조조,균제외심、간、신、혈액급풍습성질병.결과 47례천기병환인중병발관상동맥병변자17례.천기병조화대조조혈청중항β_2GP1항체수평분별위(7.46±2.13)U/ml화(4.38±0.43)U/ml;MMP-9분별위(886.62 ±92.72)ng/ml화(460±179.59)ng/ml,량조비교차이균유통계학의의(P균<0.05);천기병조중관상동맥손상여관상동맥정상환인혈청항β_2GP1항체분별위(8.83±0.89)U/ml화(6.18±1.42)U/ml,MMP-9분별위(948.62±81.76)ng/ml화(872.00±34.74)ns/ml,량조비교차이균유통계학의의(P균<0.05);천기병조혈청중항β_2CP1항체、MMP-9수평정현저정상관(r=0.665,P<0.05).결론 항β_2GP1항체、MMP-9재천기병급성기우기반관상동맥병변시명현승고,량자재천기병발생、발전과정중구유협동작용,시천기병관상동맥손상혈청학중요지표.
Objective To explore the levels and clinical significance of anti-beta 2-glycoprotein 1 antibodies (β_2GP1), matrix metalloproteinase 9 (M M P-9) in the plasma of children with Kawasaki diseases (KD). Methods Serum level of anti-β_2GP1 antibody and MMP-9 was measured in 47 children with KD by ELISA, and the data was analyzed using SPSS11.5 software. Thirty age matched children with infectious diseases(sepsis or pneumonia), exclusive of heart, liver, kidney, blood diseases and autoimmune diseases such as rheumatoid were chosen in the fever control group. Results Coronary artery lesions (CAL)were found in 17 children of KD group (17/47) by Doppler ultrasound examination. Significant differences (P < 0.05) of serum level of anti-β_2GP1 antibody was showed between KD group ((7.46 ± 2.13) U/ml)and the control group ((4.38 ± 0.43) U/ml) ; serum level of MMP-9 was (886.62 ± 92.72) ng/ml and (460.06 ± 179.59) ng/ml in KD group and the control group respectively, with significant difference between the two groups(P < 0.05). In KD group, levels of anti-β_2GP1 were (8.83 ± 0.89) U/ml among children with CAL and (6.18 ± 1.42) U/ml among children without CAL, serum level of MMP-9 was (948.62 ± 81.76) ng/ml and (872.00 ± 34.74) ug/ml respectively, with significant differences(beth P < 0.05). In children with KD, the serum levels of anti-β2GP1 antibody and MMP-9 were significantly correlated (correlation coefficient r = 0.665). Conclusions Serum levels of anti-β_2GP1 antibodies and MMP-9 increased in the acute phase of KD, and were significantly higher in those KD children with CAL.Anti-β_2GP1 antibodies and MMP-9 may play a role in the pathogenesis of KD, and can be used as an important serological indicator of KD with CAL.
