CAJ | 학술논문

不稳定斑块是微栓子的主要来源之一.微栓子信号提示患者存在不稳定斑块,近期易发生脑梗死.一系列黏附分子参与了缺血性脑损伤的炎症反应和脑微循环功能的改变.黏附分子之间的相互作用有利于白细胞黏附、迁移以及血小板聚集,促进炎症反应和血栓形成.最近的研究表明,黏附分子可能参与了微栓子的形成过程.对黏附分子和微栓子进行深入研究,有助于开发新的治疗药物和评价药物治疗的效果,对缺血性脑血管病的防治具有积极意义.
불은정반괴시미전자적주요래원지일.미전자신호제시환자존재불은정반괴,근기역발생뇌경사.일계렬점부분자삼여료결혈성뇌손상적염증반응화뇌미순배공능적개변.점부분자지간적상호작용유리우백세포점부、천이이급혈소판취집,촉진염증반응화혈전형성.최근적연구표명,점부분자가능삼여료미전자적형성과정.대점부분자화미전자진행심입연구,유조우개발신적치료약물화평개약물치료적효과,대결혈성뇌혈관병적방치구유적겁의의.
Unstable plaque is one of the major sources of microemboli.The microembolic signals indicate that the patients had unstable plaques and are prone to cerebral infarction recently.A series of adhesion molecules involved in the regulation of inflammatory response and functional changes of cerebral microcirculation during ischemic brain injury.The interaction among the adhesion molecules is conducive to leukocyte adhesion,migration,and platelet aggregation,thereby promoting inflammatory response and thrombosis.Recent studies have indicated that adhesion molecules are closely correlated with the instability of atherosclerotic plaques,which may have involved in the formation process of microemboli.The further study of adhesion molecules and microemboli contributes to implementation of drug intervention.It has a positive significance for the prevention and treatment of cerebral ischemia.