CAJ | 학술논문

Hedgehog(Hh)信号通路在果蝇、多种脊椎动物及人类胚胎发育过程中对细胞分化和增生起重要作用.该通路中各信号分子的突变、异常激活和过表达都可能导致肿瘤的发生.最近研究表明,Hh信号通路与多种恶性肿瘤侵袭和转移有密切的关系,其机制与肿瘤干细胞、上皮细胞间质转化、自分泌/旁分泌途径、肿瘤新生血管和淋巴管等有关.对Hh信号通路促进肿瘤转移机制的研究,将为恶性肿瘤的分子诊断、预后判断以及分子靶向治疗开辟新方向.
Hedgehog(Hh)신호통로재과승、다충척추동물급인류배태발육과정중대세포분화화증생기중요작용.해통로중각신호분자적돌변、이상격활화과표체도가능도치종류적발생.최근연구표명,Hh신호통로여다충악성종류침습화전이유밀절적관계,기궤제여종류간세포、상피세포간질전화、자분비/방분비도경、종류신생혈관화림파관등유관.대Hh신호통로촉진종류전이궤제적연구,장위악성종류적분자진단、예후판단이급분자파향치료개벽신방향.
The Hedgehog (Hh) signaling pathway plays a crucial role in embryo development of drosophila and a variety of vertebrate including humans,via regulating cell differentiation and proliferation.Mutation of Hh and aberrant activation or overexpression of the secreted Hh signaling molecules may induce cancer.Recent studies show that Hh signaling is associatied with invasion and metastasis in multiple types of malignant tumours.The machanisms are correlated with maintaining of cancer stem cells,epithelial-mesenchymal transition ( EMT),tumor cell autocrine/paracrine signaling and promotion of tumor angiogenesis and lymphangiogenesis.The study of mechanisms how Hh signaling promotes cancer metastasis,will provide new directions for molecular diagnosis,prognosis and molecular targeted therapy of cancer.