CAJ | 학술논문

目的了解辽宁省建平县丙型肝炎发病率、肝硬化和肝细胞癌死亡率水平异常增高情况,初步探讨其流行病学特征.方法调用辽宁省建平县居民生命统计资料和传染病发病报告数据库资料,分析建平县23个乡镇的乙型肝炎发病率、丙型肝炎发病率、肝硬化和肝细胞癌死亡率分布特征.利用乙型肝炎发病率、丙型肝炎发病率、肝硬化死亡率和肝细胞癌死亡率进行Spearman相关分析,探讨肝炎、肝硬化和肝细胞癌的相互关系.结果 2003年至2006年建平县男女肝细胞癌世界人口标准化死亡率分别为77.6/10万和22.0/10万,为辽宁省农村同期平均水平的2.0倍和1.7倍.丙型肝炎发病率为58.0/10万,为全省同期平均水平的9.5倍.丙型肝炎发病率与肝硬化死亡率(r=0.495,P=0.008)、肝硬化死亡率与肝细胞癌死亡率(r=0.646,P<0.01)呈正相关.结论辽宁省建平县丙型肝炎发病率、肝硬化和肝细胞癌死亡率水平均显著高于辽宁省同期平均水平,亟待深入调查.
목적 료해요녕성건평현병형간염발병솔、간경화화간세포암사망솔수평이상증고정황,초보탐토기류행병학특정.방법 조용요녕성건평현거민생명통계자료화전염병발병보고수거고자료,분석건평현23개향진적을형간염발병솔、병형간염발병솔、간경화화간세포암사망솔분포특정.이용을형간염발병솔、병형간염발병솔、간경화사망솔화간세포암사망솔진행Spearman상관분석,탐토간염、간경화화간세포암적상호관계.결과 2003년지2006년건평현남녀간세포암세계인구표준화사망솔분별위77.6/10만화22.0/10만,위요녕성농촌동기평균수평적2.0배화1.7배.병형간염발병솔위58.0/10만,위전성동기평균수평적9.5배.병형간염발병솔여간경화사망솔(r=0.495,P=0.008)、간경화사망솔여간세포암사망솔(r=0.646,P<0.01)정정상관.결론 요녕성건평현병형간염발병솔、간경화화간세포암사망솔수평균현저고우요녕성동기평균수평,극대심입조사.
Objective To investigate the significantly elevated incidence of hepatitis C and mortality of cirrhosis and hepatocellular carcinoma (HCC) in Jianping county, and to explore the epidemiological features. Methods The data from database of death registry and infectious disease surveillance in Jianping county, Liaoning Province were analyzed. The distributions of incidence of hepatitis B and hepatitis C, mortality of cirrhosis and HCC in 23 villages and towns were investigated.Spearman's correlation was used to explore the correlations between hepatitis, cirrhosis and HCC.Results The standardized mortality of HCC in males and females in Jianping county were 77. 6/10~5and 22. 0/10~5, respectively, which were 2. 0 and 1. 7 times, respectively of the average levels of Liaoning rural areas. The incidence of hepatitis C was 58. 0/10~5 , which was 9. 5 times of the averagelevel of Liaoning Province. There were positive correlations between incidence of hepatitis C and mortality of cirrhosis (r=0. 495, P = 0. 008), and mortality of cirrhosis and HCC (r=0. 646, P<0.01). Conclusions The incidence of hepatitis C and mortality of cirrhosis and HCC in Jianping county are significantly higher than the average levels of Liaoning Province. Further investigations of the suspected causes are needed.