中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2012年
1期
37-39
,共3页
魏薇%刘华%张淑芬%桑仲娜%张桂芹%赵娜%谭龙%张万起
魏薇%劉華%張淑芬%桑仲娜%張桂芹%趙娜%譚龍%張萬起
위미%류화%장숙분%상중나%장계근%조나%담룡%장만기
碘%孕妇%婴儿,新生%甲状腺
碘%孕婦%嬰兒,新生%甲狀腺
전%잉부%영인,신생%갑상선
Iodine%Pregnant women%Infant,newborn%Thyroid gland
目的 了解高碘地区妊娠晚期孕妇的碘营养状况,以及孕妇与新生儿甲状腺功能的关系.方法 2010年4-6月,在河北省沧州市海兴县医院收集210名妊娠晚期孕妇的空腹晨尿、静脉血,以及新生儿的脐带血,砷-铈催化分光光度法测定尿碘,化学发光法测定游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)及敏感促甲状腺激素(sTSH).结果 210名妊娠晚期孕妇年龄为(27.69±4.73)岁,尿碘中位数为1240.70μg/L,84.3％(177/210)的孕妇碘营养过量,仅有0.5％(1/210)的孕妇碘营养适宜.孕妇甲状腺疾病患病率为19.5％(41/210),各疾病顺次为:亚临床甲状腺功能减退(16.2％,34/210)、亚临床甲状腺功能亢进(0.9％,2/210)、甲状腺功能减退(2.4％,5/210)、甲状腺功能亢进(0,0/210).新生儿sTSH在5～＜10 mU/L的有104人(49.5％)；10～＜20 mU/L的有44人(21.0％),≥20 mU/L的有16人(7.6％).患甲状腺疾病的孕妇所产新生儿的sTSH水平(10.18 mU/L)和sTSH＞10 mU/L的比率(50.0％,24/48)均高于非患病孕妇(6.78 mU/L,Z=- 2.867,P＜0.05;22.2％,36/162,x2=14.000,P＜ 0.05).新生儿与母亲的sTSH水平正相关(r=0.278,P＜ 0.05),新生儿sTSH水平异常(sTSH＞10 mU/L)与母亲sTSH水平异常正相关(r=0.240,P＜ 0.05).结论 高碘地区大部分孕妇碘营养过量,新生儿sTSH水平较高且与母亲sTSH水平异常及患有甲状腺疾病有关,故应加强孕妇碘营养状况、甲状腺功能及新生儿sTSH水平的监测.
目的 瞭解高碘地區妊娠晚期孕婦的碘營養狀況,以及孕婦與新生兒甲狀腺功能的關繫.方法 2010年4-6月,在河北省滄州市海興縣醫院收集210名妊娠晚期孕婦的空腹晨尿、靜脈血,以及新生兒的臍帶血,砷-鈰催化分光光度法測定尿碘,化學髮光法測定遊離三碘甲腺原氨痠(FT3)、遊離甲狀腺素(FT4)及敏感促甲狀腺激素(sTSH).結果 210名妊娠晚期孕婦年齡為(27.69±4.73)歲,尿碘中位數為1240.70μg/L,84.3％(177/210)的孕婦碘營養過量,僅有0.5％(1/210)的孕婦碘營養適宜.孕婦甲狀腺疾病患病率為19.5％(41/210),各疾病順次為:亞臨床甲狀腺功能減退(16.2％,34/210)、亞臨床甲狀腺功能亢進(0.9％,2/210)、甲狀腺功能減退(2.4％,5/210)、甲狀腺功能亢進(0,0/210).新生兒sTSH在5～＜10 mU/L的有104人(49.5％)；10～＜20 mU/L的有44人(21.0％),≥20 mU/L的有16人(7.6％).患甲狀腺疾病的孕婦所產新生兒的sTSH水平(10.18 mU/L)和sTSH＞10 mU/L的比率(50.0％,24/48)均高于非患病孕婦(6.78 mU/L,Z=- 2.867,P＜0.05;22.2％,36/162,x2=14.000,P＜ 0.05).新生兒與母親的sTSH水平正相關(r=0.278,P＜ 0.05),新生兒sTSH水平異常(sTSH＞10 mU/L)與母親sTSH水平異常正相關(r=0.240,P＜ 0.05).結論 高碘地區大部分孕婦碘營養過量,新生兒sTSH水平較高且與母親sTSH水平異常及患有甲狀腺疾病有關,故應加彊孕婦碘營養狀況、甲狀腺功能及新生兒sTSH水平的鑑測.
목적 료해고전지구임신만기잉부적전영양상황,이급잉부여신생인갑상선공능적관계.방법 2010년4-6월,재하북성창주시해흥현의원수집210명임신만기잉부적공복신뇨、정맥혈,이급신생인적제대혈,신-시최화분광광도법측정뇨전,화학발광법측정유리삼전갑선원안산(FT3)、유리갑상선소(FT4)급민감촉갑상선격소(sTSH).결과 210명임신만기잉부년령위(27.69±4.73)세,뇨전중위수위1240.70μg/L,84.3％(177/210)적잉부전영양과량,부유0.5％(1/210)적잉부전영양괄의.잉부갑상선질병환병솔위19.5％(41/210),각질병순차위:아림상갑상선공능감퇴(16.2％,34/210)、아림상갑상선공능항진(0.9％,2/210)、갑상선공능감퇴(2.4％,5/210)、갑상선공능항진(0,0/210).신생인sTSH재5～＜10 mU/L적유104인(49.5％)；10～＜20 mU/L적유44인(21.0％),≥20 mU/L적유16인(7.6％).환갑상선질병적잉부소산신생인적sTSH수평(10.18 mU/L)화sTSH＞10 mU/L적비솔(50.0％,24/48)균고우비환병잉부(6.78 mU/L,Z=- 2.867,P＜0.05;22.2％,36/162,x2=14.000,P＜ 0.05).신생인여모친적sTSH수평정상관(r=0.278,P＜ 0.05),신생인sTSH수평이상(sTSH＞10 mU/L)여모친sTSH수평이상정상관(r=0.240,P＜ 0.05).결론 고전지구대부분잉부전영양과량,신생인sTSH수평교고차여모친sTSH수평이상급환유갑상선질병유관,고응가강잉부전영양상황、갑상선공능급신생인sTSH수평적감측.
Objective To find out iodine nutritional status of pregnant women in the third trimester and the relationship between pregnant women and their neonates thyroid function in a high iodine area.Methods From April to June 2010,210 copies of fasting morning urine and venous blood,and their neonatal umbilical cord blood samples were collected in Haixing Hospital,Cangzhou city,Hebei province.Urinary iodine was determined by arsenic-cerium catalytic spectrophotometry.The levels of free triiodothyronine(FT3),free thyroxine (FT4) and sensitive thyroid-stimulating hormone (sTSH) in serum were measured by chemiluminescence.Results Median urinary iodine of 210 pregnant women(average age 27.69 ± 4.73 years) in the third trimester was 1240.70 μg/L,84.3％(177/210) of them was in excessive iodine nutrition,and only 0.5％(1/210) of them was in adequate iodine nutrition.The prevalence rate of thyroid diseases was 19.5％ (41/210),and the spectrum of diseases were subclinical hypothyroidism(16.2％,34/210),subclinical hyperthyroidism(0.9％,2/210),hypothyroidism(2.4％,5/210) and hyperthyroidism (0,0/210).The number of newborns with sTSH 5 - ＞ 10 mU/L were 104 persons (49.5％); 10 - ＞ 20 mU/L were 44 persons(21.0％),and ≥20 mU/L were 16 persons(7.6％).Of pregnant women suffer from thyroid disease,the ratio(50.0％,24/48 ) of sTSH equal to 10.18 mU/L and ＞ 10 mU/L of their neonates was higher than that of their corresponding non-ill pregnant women(6.78 mU/L,Z =- 2.867,P ＜ 0.05; 22.2％,36/162,x2 =14.000,P ＜ 0.05).There was a positive correlation between neonates' and their mothers' sTSH levels (r =0.278,P ＜ 0.05).There was also a positive correlation between neonates' (sTSH ＞ 10 mU/L) and their mothers' abnormal sTSH levels (r =0.240,P ＜ 0.05).Conclusions Most of the pregnant women in high iodine areas are iodine excess.The level of neonates' sTSH is higher,and it is due to their mothers' abnormal sTSH and suffering from thyroid diseases to some extent.As a result,the monitoring of pregnant women's iodine nutrition and thyroid function and sTSH level of their neonates should be strengthened.
