中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
8期
667-670
,共4页
程永静%王芳%张春媚%高利云%郑利%徐华%高明%黄慈波
程永靜%王芳%張春媚%高利雲%鄭利%徐華%高明%黃慈波
정영정%왕방%장춘미%고리운%정리%서화%고명%황자파
干燥综合征%白细胞减少%自身抗体
榦燥綜閤徵%白細胞減少%自身抗體
간조종합정%백세포감소%자신항체
Sjogren's syndrome%Leukopenia%Antibodies
目的 探讨不同年龄原发性干燥综合征(pSS)患者的临床、实验室检查及治疗特点.方法 收集84例干燥综合征患者的临床资料,按年龄分为中青年组和老年组,回顾性分析其临床特点、实验室指标及药物治疗的差异,并应用卡方检验进行统计学分析.结果 干燥综合征患者84例,老年组30例,中青年组54例;老年组患者口干、眼干及猖獗龋的阳性率分别为80.0%、76.7%及43.3%,明显高于中青年组57.4%、51.9%及20.4%(均为P＜0.05);类风湿因子(RF)升高、抗SSA抗体及抗SSB抗体阳性的机率分别为13.0%、36.7%及16.7%,明显低于中青年组44.4%、59.3%及42.6%(均为P＜0.05);老年组与中青年组比较,眼科特异性检查的阳性率(Schirmer实验,角膜荧光染色,泪膜破裂时间)、腮腺同位素显影的阳性率、免疫球蛋白升高(IgG,IgA,IgM)均差异无统计学意义;老年组白细胞减低及甲状腺受累的阳性率分别为13.3%及10.0%,均低于中青年组48.1%及37.0%(P＜0.05).老年组患者应用白芍总苷单药治疗的比例(33.3%)高于中青年组(14.8%)(P＜0.05),而用羟氯喹治疗的比例(16.7%)低于中青年组(40.7%)(P＜0.05).结论 老年干燥综合征患者口干、眼干及猖獗龋等临床症状及体征更为典型,抗SSA抗体及抗SSB抗体等特异性抗体的阳性率略低,合并白细胞减低及甲状腺疾病的机率低,诊断更多的依赖唇腺活检.
目的 探討不同年齡原髮性榦燥綜閤徵(pSS)患者的臨床、實驗室檢查及治療特點.方法 收集84例榦燥綜閤徵患者的臨床資料,按年齡分為中青年組和老年組,迴顧性分析其臨床特點、實驗室指標及藥物治療的差異,併應用卡方檢驗進行統計學分析.結果 榦燥綜閤徵患者84例,老年組30例,中青年組54例;老年組患者口榦、眼榦及猖獗齲的暘性率分彆為80.0%、76.7%及43.3%,明顯高于中青年組57.4%、51.9%及20.4%(均為P＜0.05);類風濕因子(RF)升高、抗SSA抗體及抗SSB抗體暘性的機率分彆為13.0%、36.7%及16.7%,明顯低于中青年組44.4%、59.3%及42.6%(均為P＜0.05);老年組與中青年組比較,眼科特異性檢查的暘性率(Schirmer實驗,角膜熒光染色,淚膜破裂時間)、腮腺同位素顯影的暘性率、免疫毬蛋白升高(IgG,IgA,IgM)均差異無統計學意義;老年組白細胞減低及甲狀腺受纍的暘性率分彆為13.3%及10.0%,均低于中青年組48.1%及37.0%(P＜0.05).老年組患者應用白芍總苷單藥治療的比例(33.3%)高于中青年組(14.8%)(P＜0.05),而用羥氯喹治療的比例(16.7%)低于中青年組(40.7%)(P＜0.05).結論 老年榦燥綜閤徵患者口榦、眼榦及猖獗齲等臨床癥狀及體徵更為典型,抗SSA抗體及抗SSB抗體等特異性抗體的暘性率略低,閤併白細胞減低及甲狀腺疾病的機率低,診斷更多的依賴脣腺活檢.
목적 탐토불동년령원발성간조종합정(pSS)환자적림상、실험실검사급치료특점.방법 수집84례간조종합정환자적림상자료,안년령분위중청년조화노년조,회고성분석기림상특점、실험실지표급약물치료적차이,병응용잡방검험진행통계학분석.결과 간조종합정환자84례,노년조30례,중청년조54례;노년조환자구간、안간급창궐우적양성솔분별위80.0%、76.7%급43.3%,명현고우중청년조57.4%、51.9%급20.4%(균위P＜0.05);류풍습인자(RF)승고、항SSA항체급항SSB항체양성적궤솔분별위13.0%、36.7%급16.7%,명현저우중청년조44.4%、59.3%급42.6%(균위P＜0.05);노년조여중청년조비교,안과특이성검사적양성솔(Schirmer실험,각막형광염색,루막파렬시간)、시선동위소현영적양성솔、면역구단백승고(IgG,IgA,IgM)균차이무통계학의의;노년조백세포감저급갑상선수루적양성솔분별위13.3%급10.0%,균저우중청년조48.1%급37.0%(P＜0.05).노년조환자응용백작총감단약치료적비례(33.3%)고우중청년조(14.8%)(P＜0.05),이용간록규치료적비례(16.7%)저우중청년조(40.7%)(P＜0.05).결론 노년간조종합정환자구간、안간급창궐우등림상증상급체정경위전형,항SSA항체급항SSB항체등특이성항체적양성솔략저,합병백세포감저급갑상선질병적궤솔저,진단경다적의뢰진선활검.
Objective To investigate the differences in clinical, laboratory and therapeutic aspects of primary Sjogren's syndrome (pSS) between young/middle-age group and old group.Methods The 84 pSS patients were divided into the young and middle-age group (n=54) and the old group (n = 30). The differences in clinical features, laboratory indices and drug therapy were retrospectively analyzed. The chi-square test was used for statistical analysis. Results The positive incidences of xerostomia, dry eye symptom and rampant teeth were 80.0%, 76.7% and 43.3%respectively in the old group. And they were all significantly higher than in young and middle-aged group (57.4%, 51.9% and 20.4%, all P＜0. 05). The positive rates of rheumatoid factor (RF)elevation, antiRo/SSA and antiLa/SSB antibodies were 13. 0%, 36.7% and 16.7% in the old group,and significantly lower than in young and middle-age group (44.4%, 59.3% and 42.6%, all P＜0.05). The incidences of leukopenia and thyroid gland involvement were much lower in the aged group (13.3% and 10.0%) than in the young and middle-age group (48. 1% and 37.0%, P＜0. 05). The percentage of patients receiving hydroxychloroquine as the main medicine was much lower in the aged group than in the young and middle-age group (16.7% vs. 40. 7%, P＜0. 05), while percentage of treatment with exclusive glucosides of Paeony Capsules was much higher (33.3% vs. 14.8%, P＜0.05). There were no statistical differences between two groups in ophthalmological examination,immunoglobulin level and sialography. Conclusions Those pSS patients with late onset exhibit more abnormalities in clinical parameters, but fewer in immunological parameters, which may be helpful in estimating prognosis and pathogenetic factors in pSS.
