CAJ | 학술논문

检测76例子宫内膜异位症(EMS)患者(EMS组)(Ⅰ、Ⅱ期36例,Ⅲ、Ⅳ期40例)和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者(对照组)腹腔液及血清高迁移率蛋白-1(HMGB1)、高敏C反应蛋白(Hs-CRP)含量.EMS组患者腹腔液中HMGB1、Hs-CRP的含量明显高于对照组,(8.2±0.8)mg/L比(2.1±0.2)mg/L、(14.4±3.0)mg/L比(4.5±2.3)mg/L(均P＜0.01).Ⅲ、Ⅳ期EMS患者腹腔液中HMGB1、Hs-CRP的含量较Ⅰ、Ⅱ期患者升高,(9.2±0.8)mg/L比(6.7±0.7)mg/L、(18.7±2.9)mg/L比(11.2±2.8)mg/L,差异有统计学意义(均P＜0. 05),同时Ⅲ、Ⅳ期EMS患者血清中HMGB1、Hs-CRP的含量也高于Ⅰ、Ⅱ期患者,(6.5±0.6)mg/L比(3.4±0.5)mg/L、(8.4±2.7)mg/L比(5.4±2.4)mg/L.同时EMS组患者HMGB1与Hs-CRP的含量之间存在正相关(r=0.72,P＜0.01).EMS患者高含量的HMGB1与Hs-CRP可作为判断EMS病情的参考指标.
검측76례자궁내막이위증(EMS)환자(EMS조)(Ⅰ、Ⅱ기36례,Ⅲ、Ⅳ기40례)화30례인란소낭종혹장막하자궁기류수술환자(대조조)복강액급혈청고천이솔단백-1(HMGB1)、고민C반응단백(Hs-CRP)함량.EMS조환자복강액중HMGB1、Hs-CRP적함량명현고우대조조,(8.2±0.8)mg/L비(2.1±0.2)mg/L、(14.4±3.0)mg/L비(4.5±2.3)mg/L(균P＜0.01).Ⅲ、Ⅳ기EMS환자복강액중HMGB1、Hs-CRP적함량교Ⅰ、Ⅱ기환자승고,(9.2±0.8)mg/L비(6.7±0.7)mg/L、(18.7±2.9)mg/L비(11.2±2.8)mg/L,차이유통계학의의(균P＜0. 05),동시Ⅲ、Ⅳ기EMS환자혈청중HMGB1、Hs-CRP적함량야고우Ⅰ、Ⅱ기환자,(6.5±0.6)mg/L비(3.4±0.5)mg/L、(8.4±2.7)mg/L비(5.4±2.4)mg/L.동시EMS조환자HMGB1여Hs-CRP적함량지간존재정상관(r=0.72,P＜0.01).EMS환자고함량적HMGB1여Hs-CRP가작위판단EMS병정적삼고지표.
The concentrations of prostaglandin in high mobility group box-1 ( HMGB1 ) and highsensitive C-reactive protein (Hs-CRP) in serum and peritoneal fluid were detected in 76 patients with endometriosis (study group) and 30 patients without endometriosis (ovary cysts or uterine myoma, as control group). The peritoneal fluids were collected during laparoscopic operation, and the serum samples were collected before surgery. The HMGB1 and Hs-CRP concentrations in serum and peritoneal fluid of study group were significantly higher than those of control group, ( 8. 2 ± 0. 8) mg/L vs. (2. 1 ±. 0. 2) mg/L、 ( 14. 4 ±3.0) mg/L vs. (4.5 ±2.3) mg/L (both P＜0. 01);HMGB1 and Hs-CRP levels in serum and peritoneal fluid of stage Ⅲ-Ⅳ endometriosis were significantly higher than those of stage Ⅰ-Ⅱ, ( 9. 2 ± 0. 8) mg/L vs.(6.7 ±0.7) mg/L,(18.7 ±2.9) mg/L vs. (11.2 ±2. 8) mg/L,(6.5 ±0.6) mg/L vs. (3.4 ±0.5) mg/L,(8.4 ±2.7) mg/L vs. (5.4 ±2.4) mg/L (all P ＜0.05). The concentrations of HMGB1 were positively correlated with Hs-CRP in endometriosis group (r =0. 72, P ＜0. 01 ). The results indicate that concentrations of HMGB1 and Hs-CRP may be of value in assessing the severity of endometrosis.