中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2008年
4期
299-301
,共3页
赵健%周金年%杨英捷%廖秦平
趙健%週金年%楊英捷%廖秦平
조건%주금년%양영첩%료진평
肿瘤,鳞状细胞%官颈疾病%阴道镜检查%乳头状瘤病毒,人
腫瘤,鱗狀細胞%官頸疾病%陰道鏡檢查%乳頭狀瘤病毒,人
종류,린상세포%관경질병%음도경검사%유두상류병독,인
Neoplasms,squamous cell%Cervix diseases%Colpascopy%Papillomavims,human
目的 探讨人乳头状瘤病毒(human papillomavirus,HPV)分型检测在宫颈细胞学诊断为不典型鳞状细胞意义不明确(atypical squamous cell of undetermined significance.ASCUS)分层处理中的意义.方法 对184例宫颈细胞学诊断为ASCUS的患者,分别进行HPV检测和阴道镜下宫颈组织活检.结果 184例宫颈细胞学诊断为ASCUS的患者中,经组织病理学证实炎症112例(60.87%),CIN Ⅰ级33例(17.93%),CIN Ⅱ级17例(9.24%),CIN Ⅲ级8例(4.35%),宫颈鳞癌4例(2.17%),宫颈湿疣10例(5.43%).其中124例经检测呈高危型HPV(high-risk types HPV,HR-HPV)阳性,阳性率为67.39%(124/184),随后经病理学证实炎症66例(53.23%),CIN Ⅰ级22例(17.74%),CIN Ⅱ级16例(12.90%),CIN Ⅲ级8例(6.45%),宫颈鳞癌4例(3.23%),宫颈湿疣8例(6.45%).HPV阳性组CIN以上病变检出率明显高于HPV阴性组(P<0.003).结论对宫颈细胞学诊断为ASCUS的患者,建议作HPV检测,若HR-HPV阳性,则需进一步阴道镜下宫颈活检;若HPV阴性,酌情处理.
目的 探討人乳頭狀瘤病毒(human papillomavirus,HPV)分型檢測在宮頸細胞學診斷為不典型鱗狀細胞意義不明確(atypical squamous cell of undetermined significance.ASCUS)分層處理中的意義.方法 對184例宮頸細胞學診斷為ASCUS的患者,分彆進行HPV檢測和陰道鏡下宮頸組織活檢.結果 184例宮頸細胞學診斷為ASCUS的患者中,經組織病理學證實炎癥112例(60.87%),CIN Ⅰ級33例(17.93%),CIN Ⅱ級17例(9.24%),CIN Ⅲ級8例(4.35%),宮頸鱗癌4例(2.17%),宮頸濕疣10例(5.43%).其中124例經檢測呈高危型HPV(high-risk types HPV,HR-HPV)暘性,暘性率為67.39%(124/184),隨後經病理學證實炎癥66例(53.23%),CIN Ⅰ級22例(17.74%),CIN Ⅱ級16例(12.90%),CIN Ⅲ級8例(6.45%),宮頸鱗癌4例(3.23%),宮頸濕疣8例(6.45%).HPV暘性組CIN以上病變檢齣率明顯高于HPV陰性組(P<0.003).結論對宮頸細胞學診斷為ASCUS的患者,建議作HPV檢測,若HR-HPV暘性,則需進一步陰道鏡下宮頸活檢;若HPV陰性,酌情處理.
목적 탐토인유두상류병독(human papillomavirus,HPV)분형검측재궁경세포학진단위불전형린상세포의의불명학(atypical squamous cell of undetermined significance.ASCUS)분층처리중적의의.방법 대184례궁경세포학진단위ASCUS적환자,분별진행HPV검측화음도경하궁경조직활검.결과 184례궁경세포학진단위ASCUS적환자중,경조직병이학증실염증112례(60.87%),CIN Ⅰ급33례(17.93%),CIN Ⅱ급17례(9.24%),CIN Ⅲ급8례(4.35%),궁경린암4례(2.17%),궁경습우10례(5.43%).기중124례경검측정고위형HPV(high-risk types HPV,HR-HPV)양성,양성솔위67.39%(124/184),수후경병이학증실염증66례(53.23%),CIN Ⅰ급22례(17.74%),CIN Ⅱ급16례(12.90%),CIN Ⅲ급8례(6.45%),궁경린암4례(3.23%),궁경습우8례(6.45%).HPV양성조CIN이상병변검출솔명현고우HPV음성조(P<0.003).결론대궁경세포학진단위ASCUS적환자,건의작HPV검측,약HR-HPV양성,칙수진일보음도경하궁경활검;약HPV음성,작정처리.
Objective To investigate the significance of human papillomavirus teat in triage of patients with atypical squamoas cell of undetermined significance (ASCUS) diagnosed by cervical cytology. Methods Human papillomavirus teat,colposcope and cervical biopsy were performed in 184 patients with a referral diagnosis of ASCUS by cervical cytology. Results Confirmed by pathological diagnosis of cervical biopsy, 112 cases were chronic inflammation(60.87%),33 CIN Ⅰ (17.93%),17 CIN Ⅱ (9.24%),8 CIN Ⅲ (4.35%),4 cervical squamous carcinoma (2.17%) and 10 condyloma (5.43%). Of the 184 women with cytological ASCUS, 124(67.39%) cases were positive in high-risk HPV test among which 66 cases were histologically confirmed as chronic inflammation(53.23%),22 as GIN Ⅰ(17.74%), 16 as CIN Ⅱ(12.90% ), 8 as CIN Ⅲ(6.45%) ,4 as cervical squamoas carcinoma (3.23%) and 8 as condyloma (6.45%). The positive rate of HPV in groups of ASCUS were higher than those with negative HPV (P<0.003). Conclusion Women with ASCUS should be tested for HPV. Cervical biopsy under colposcopy is recommended for women with HR-HPV infection.
