中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
22期
1540-1542
,共3页
袁东红%谢华红%王燕%孟存英%杨利萍%冯亦朝%宋久刚%邹学%吴开春%刘杰
袁東紅%謝華紅%王燕%孟存英%楊利萍%馮亦朝%宋久剛%鄒學%吳開春%劉傑
원동홍%사화홍%왕연%맹존영%양리평%풍역조%송구강%추학%오개춘%류걸
肠肿瘤%免疫组织化学%磷脂酰肌醇蛋白聚糖3
腸腫瘤%免疫組織化學%燐脂酰肌醇蛋白聚糖3
장종류%면역조직화학%린지선기순단백취당3
Intestinal neoplasms%Immunohistochemistry%Glypican-3
目的 探讨磷脂酰肌醇蛋白聚糖3(Glypican-3)在大肠癌组织及癌旁组织中的表达、分布及意义.方法 采用免疫组化方法检测Glypican-3在200例大肠癌及其癌旁组织中的表达,分析其表达的意义.结果 大肠癌中Glypican-3阳性率为66.0%(132/200),明显高于癌旁组织[24.0%(48/200)],差异有统计学意义(P=0.019).Glypican-3的表达与大肠癌组织浆膜浸润、淋巴结转移有相关性(P=0.015).结论 Glypican-3在人大肠癌中表达增加,与大肠癌的浸润、淋巴结转移相关.
目的 探討燐脂酰肌醇蛋白聚糖3(Glypican-3)在大腸癌組織及癌徬組織中的錶達、分佈及意義.方法 採用免疫組化方法檢測Glypican-3在200例大腸癌及其癌徬組織中的錶達,分析其錶達的意義.結果 大腸癌中Glypican-3暘性率為66.0%(132/200),明顯高于癌徬組織[24.0%(48/200)],差異有統計學意義(P=0.019).Glypican-3的錶達與大腸癌組織漿膜浸潤、淋巴結轉移有相關性(P=0.015).結論 Glypican-3在人大腸癌中錶達增加,與大腸癌的浸潤、淋巴結轉移相關.
목적 탐토린지선기순단백취당3(Glypican-3)재대장암조직급암방조직중적표체、분포급의의.방법 채용면역조화방법검측Glypican-3재200례대장암급기암방조직중적표체,분석기표체적의의.결과 대장암중Glypican-3양성솔위66.0%(132/200),명현고우암방조직[24.0%(48/200)],차이유통계학의의(P=0.019).Glypican-3적표체여대장암조직장막침윤、림파결전이유상관성(P=0.015).결론 Glypican-3재인대장암중표체증가,여대장암적침윤、림파결전이상관.
Objective To investigate the expression and significance of Glypican-3 in colorectal cancer.Methods Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation.Results Glypican-3 immunoreactivity was recognized in both the cytoplasm and cellular membrane.The Glypican-3 positive expression rate in the tumor samples Was 66.0% (132/200),significantly higher than that in the adjacent nontumor tissues(24%,48/200,P=0.019).The Glypican-3 expression rate was significantly correlated with the carcinoma invasion (P=0.023) and lymph node metastasis (P=0.015),but not associated with gender,age,tumor size,and difierentiation grade (all P>0.05).Conclusion Over-expression of Glypican-3 may play an important role in the genesis and development of colorectal cancer,and may be used as a new biological parameter in predicting invasion and metastasis of colorectal carcinoma.
