CAJ | 학술논문

目的探讨超选择动脉内灌注化疗加栓寒术前治疗晚期子宫颈癌的临床疗效.方法 2004年1月至2008年3月间住院未经治疗的ⅡA～Ⅳ期子宫颈癌患者共26例,术前在数字减影血管造影术监视下,采用Seldinger技术行双侧髂内动脉插管灌注化疗药,卡铂80 mg,长春新碱2 mg,丝裂霉素16 mg,明胶海绵颗粒栓塞肿瘤供血明显的分支.妇科检查结合超声和CT测量化疗前后肿瘤大小,计算肿瘤消退百分比.1个月后行根治性子宫切除术.结果栓塞化疗总有效率为92.3%.结论术前化疗可缩小肿瘤病灶,减少淋巴结转移和亚临床播散,增加了根治性子宫切除的机会,有望提高晚期子宫颈癌患者的生活质量和生存率.
목적 탐토초선택동맥내관주화료가전한술전치료만기자궁경암적림상료효.방법 2004년1월지2008년3월간주원미경치료적ⅡA～Ⅳ기자궁경암환자공26례,술전재수자감영혈관조영술감시하,채용Seldinger기술행쌍측가내동맥삽관관주화료약,잡박80 mg,장춘신감2 mg,사렬매소16 mg,명효해면과립전새종류공혈명현적분지.부과검사결합초성화CT측양화료전후종류대소,계산종류소퇴백분비.1개월후행근치성자궁절제술.결과 전새화료총유효솔위92.3%.결론 술전화료가축소종류병조,감소림파결전이화아림상파산,증가료근치성자궁절제적궤회,유망제고만기자궁경암환자적생활질량화생존솔.
Objective To investigate the clinical effect of superselective arterial infusion chemotherapy(SACT) and embolization in advanced cervical carcinoma patients before surgery. Methods 26 previously untreated patients with stage ⅡA-Ⅳ cervical carcinoma admitted from January 2004 to March 2008 were enrolled into the study, patients underwent SACT of the internal iliac artery(dose of the drug: CBP 80 rag, VCR 2 rag, MMC 16 mg) by Seldinger technique in the surveillance of DSA, the obvious branches of the tumor blood supply were embolized by gelfoam particles. Size of tumor before and after chemotherapy was measured by gynecological examination combined with B ultrasonic examination and CT, then calculated the percentage of tumor regression. Radical hysterectomy was administered one month after chemotherapy. Results 24 patients were evaluated as PR, the reaction rate of chemotherapy was 92.3 %. Conclusion SACT before surgery can effectively reduce tumor volume, decrease lymphatic metastasis and subclinical dissemination and enhance the opportunity of radical hysterectomy, and to improve the quality of life and OS of the advanced cervical carcinoma patients.