肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
5期
323-325
,共3页
姜永全%白晓鸣%柴立勋%冯爱爱
薑永全%白曉鳴%柴立勛%馮愛愛
강영전%백효명%시립훈%풍애애
食管肿瘤%肿瘤鳞状细胞%Ezrin蛋白%c-met%免疫组织化学
食管腫瘤%腫瘤鱗狀細胞%Ezrin蛋白%c-met%免疫組織化學
식관종류%종류린상세포%Ezrin단백%c-met%면역조직화학
Esophageal neoplasms%Neoplasms,squamous cell%Ezrin protein%c-met%Immunohistochemistry
目的 探讨Ezrin蛋白和c-met在食管鳞癌中的表达及其在食管鳞癌发生、发展中的作用.方法 应用免疫组织化学(SP)法检测50例食管鳞癌患者癌组织标本及癌旁正常上皮组织中Ezrin蛋白和c-met的表达情况,并结合临床相关因因素进行分析.结果 在50例癌旁上正常上皮组织中,Ezrin蛋白阳性表达率为34.0%,c-met阳性表达率为8.0%,而在50例食管鳞癌组织中Ezrin蛋白阳性表达率为76.0%,c-met阳性表达率为58.0%.Ezrin蛋白在食管鳞癌组织中的表达与浸润深度和有无淋巴转移有关(P<0.05).c-met在食管鳞癌组织中的表达与有无淋巴转移有关(P<0.05).c-met阳性表达组Ezrin蛋白表达阳性率显著高于c-met阴性表达组(P<0.05).结论 联合榆测Ezrin与c-met的表达能够综合判断食管鳞癌的恶性程度和其潜在的转移能力,Ezrin蛋白有望成为一个肿瘤转移的标志物和预后的评价指标.
目的 探討Ezrin蛋白和c-met在食管鱗癌中的錶達及其在食管鱗癌髮生、髮展中的作用.方法 應用免疫組織化學(SP)法檢測50例食管鱗癌患者癌組織標本及癌徬正常上皮組織中Ezrin蛋白和c-met的錶達情況,併結閤臨床相關因因素進行分析.結果 在50例癌徬上正常上皮組織中,Ezrin蛋白暘性錶達率為34.0%,c-met暘性錶達率為8.0%,而在50例食管鱗癌組織中Ezrin蛋白暘性錶達率為76.0%,c-met暘性錶達率為58.0%.Ezrin蛋白在食管鱗癌組織中的錶達與浸潤深度和有無淋巴轉移有關(P<0.05).c-met在食管鱗癌組織中的錶達與有無淋巴轉移有關(P<0.05).c-met暘性錶達組Ezrin蛋白錶達暘性率顯著高于c-met陰性錶達組(P<0.05).結論 聯閤榆測Ezrin與c-met的錶達能夠綜閤判斷食管鱗癌的噁性程度和其潛在的轉移能力,Ezrin蛋白有望成為一箇腫瘤轉移的標誌物和預後的評價指標.
목적 탐토Ezrin단백화c-met재식관린암중적표체급기재식관린암발생、발전중적작용.방법 응용면역조직화학(SP)법검측50례식관린암환자암조직표본급암방정상상피조직중Ezrin단백화c-met적표체정황,병결합림상상관인인소진행분석.결과 재50례암방상정상상피조직중,Ezrin단백양성표체솔위34.0%,c-met양성표체솔위8.0%,이재50례식관린암조직중Ezrin단백양성표체솔위76.0%,c-met양성표체솔위58.0%.Ezrin단백재식관린암조직중적표체여침윤심도화유무림파전이유관(P<0.05).c-met재식관린암조직중적표체여유무림파전이유관(P<0.05).c-met양성표체조Ezrin단백표체양성솔현저고우c-met음성표체조(P<0.05).결론 연합유측Ezrin여c-met적표체능구종합판단식관린암적악성정도화기잠재적전이능력,Ezrin단백유망성위일개종류전이적표지물화예후적평개지표.
Objective To investigate the expression of Ezrin protein and c-met in esophageal squamous cell carcinoma, their significance in the progress of esophageal squamous cell carcinoma development and metastasis. Methods The expression of Ezrin protein and c-met in 50 patients with esophageal squamous cell carcinoma was studied using immunohistochemical (SP) method. The correlation of each score according to the intensity and percentage of labeled cells or intercellular substance with relevant clinical data was statistically analyzed. Results In normal esophageal squamous epithelium, the positive expression of Ezrin protein was 34 %, the positive expression of c-met was 8.0 %. In esophageal squamous cell carcinoma, the positive expression of Ezrin protein was 76.0 %, the positive expression of c-met was 58.0 %. The expression of Ezrin protein had close relation to depth of invasion and lymph node metastasis(P < 0.05). The positive rate of c-met protein expression in lymph node metastasis was obviously higher than those without lymph node metasis (P <0.05). The expressinn of Ezrin protein in c-met positive eases was obviously higher than those of c-met negative cases(P <0.05). Conclusion The test of Ezrin protein and c-met may have significant prognostic value for assessing the degree of malignancy and potential lymph node metastasis probability of esophageal squamous cell carcinoma. Ezrin protein may be a target to evaluate the tumor prognosis.
