CAJ | 학술논문

目的：探讨原发性高血压（EH）、脑出血（CH）、脑梗死（CI）患者血浆和红细胞镁、钠水平，及红细胞镁/钠交换速率与胰岛素抵抗（IR）的相关性。方法：用原子吸收光谱火焰法测定23例EH、21例CH和34例CI急慢性患者及20例正常对照组的血浆和红细胞镁、钠水平。以红细胞加镁负荷试验测定总镁外流最大速率（VTmax）钠依赖与非依赖性镁外流最大速率，并按ISI法评定胰岛素抵抗。结果：与对照组相比，EH组红细胞镁含量（EMC）明显减少（P＜0.05），钠依赖性镁外流最大速率（VNDmax）、VTmax明显加快（P＜0.05）；CH、C I急慢性期组患者EMC减少非常显著（P＜0.05～0.001），红细胞钠含量（ENC）增加非常显著（P＜0.05～0.01），VNDmax、VTmax加快非常显著（P＜0 .05～0.01）。ISI与EMC、VNDmax呈负相关，与ENC呈正相关。结论：EH，特别是脑卒中患者EMC显著增加，ENC显著减少。它可能参与了胰岛素抵抗的发生和发展，，从而影响动脉粥样硬化过程。
목적：탐토원발성고혈압（EH）、뇌출혈（CH）、뇌경사（CI）환자혈장화홍세포미 、납수평，급홍세포미/납교환속솔여이도소저항（IR）적상관성。 방법：용원자흡수광보 화염법측정23례EH、21례CH화34례CI급만성환자급20례정상대조조적혈장화홍세포미、납수 평。이홍세포가미부하시험측정총미외류최대속솔（VTmax）납의뢰여비의뢰성미외 류최대속솔，병안ISI법평정이도소저항。 결과：여대조조상비，EH조홍세포미함량（EMC）명현감소（P＜0.05），납의뢰성미외류최 대속솔（VNDmax）、VTmax명현가쾌（P＜0.05）；CH、C I급만성기조환자EMC감소비상현저（P＜0.05～0.001），홍세포납함량（ENC）증가 비상현저（P＜0.05～0.01），VNDmax、VTmax가쾌비상현저（P＜0 .05～0.01）。ISI여EMC、VNDmax정부상관，여ENC정정상관。 결론：EH，특별시뇌졸중환자EMC현저증가，ENC현저감소。타 가능삼여료이도소저항적발생화발전，，종이영향동맥죽양경화과정。
Objective:To investigate the plasma sodium(PNa) 、magnesium (PMg) lev els, erythrocyte sodium content (ENC)、magnesium content(EMC) , erythrocyte Na +/ Mg2+ exchange rate and its correlation with insulin resistance(IR) in pati ents with essential hypertension(EH), cerebral hemorrhage(CH), cerebral infarcti on(CI).Methods:PNa、PMg, 、ENC、EMC and Na+/Mg2+ exchange rate were measured by flame assay of atomic absorption spectrophotometer. Total magnesium efflux(VTmax ), sodium-dependent magnesium efflux(VNDmax) were measured by supplyin g magnesium test. IR was evaluated by ISI method.Results: Compared with control group, EMC de creased (P＜0.05), VTmax、VNDmax accelerated(P＜0.05) in E H group;EMC signifi cantly decreased (P＜0.05～0.001), ENC significantly increased (P＜0. 05～0.01), VTmax、VNDmax significantly accelerated(P＜0.05～0.001) in CH 、CI group. There were significantly negative correlation(P＜0.05～0.01) among ISI and EMC、 VNDmax ,and there was significantly positive correlation(P＜0.05～0.01) between I SI and ENC. Conclusion:EMC decrease, VTmax、VNDmax accelerate in E H group, particularly in stroke. It may take part in happen of IR and influence process of atherosclerosis.