CAJ | 학술논문

为了考察pH对利多卡因经皮渗透性的影响,用水平扩散池测定了盐酸利多卡因在不同pH值下通过离体大鼠皮肤的稳态流量(Jss)等参数.结果表明利多卡因游离碱和盐酸盐的经皮渗透性有明显差别,前者的稳态流量为后者的14倍,且滞后时间较短,稳态流量对pH作图呈"S"形曲线,pH接近pKa时稳态流量突增.由此可见,介质的pH值影响利多卡因的经皮渗透性,制剂中应作为一个重要因素考察.
위료고찰pH대리다잡인경피삼투성적영향,용수평확산지측정료염산리다잡인재불동pH치하통과리체대서피부적은태류량(Jss)등삼수.결과표명리다잡인유리감화염산염적경피삼투성유명현차별,전자적은태류량위후자적14배,차체후시간교단,은태류량대pH작도정"S"형곡선,pH접근pKa시은태류량돌증.유차가견,개질적pH치영향리다잡인적경피삼투성,제제중응작위일개중요인소고찰.
The effect of pH on the permeation of Lidocaine hydrochloride (LH) across excised rat skin was studied,the steady state flux (Jss) at different pH being determined using improved Valia-Chien diffusion cells. Jss curve. Jss of Lidocaine free base (LFB) was fourteen times that of LH. The pH of vehicle influences the permeation of LH significantly and should be considered as an important factor when a formulation is developed.