中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2009年
12期
931-933
,共3页
严翠霞%江文明%陈桂良%杨永健%王麟达
嚴翠霞%江文明%陳桂良%楊永健%王麟達
엄취하%강문명%진계량%양영건%왕린체
沙美特罗替卡松粉吸入剂%沙美特罗%内酸氟替卡松%高效液相色谱%测定
沙美特囉替卡鬆粉吸入劑%沙美特囉%內痠氟替卡鬆%高效液相色譜%測定
사미특라체잡송분흡입제%사미특라%내산불체잡송%고효액상색보%측정
salmeterol xinafoate and fluticasone propionate powder for inhalation%salmeterol%fluticasone propionate%HPLC%determination
建立了HPLC法测定沙美特罗替卡松粉吸入剂中的沙美特罗和丙酸氟替卡松.采用C_(18)色谱柱,以甲醇-0.05 mol/L乙酸铵溶液(68:32)为流动相,检测波长228 nm.沙美特罗和丙酸氟替卡松分别在0.14～27.4 μg/ml和0.3～60μg/ml浓度范围内线性关系良好;回收率为101.3%和101.5%.
建立瞭HPLC法測定沙美特囉替卡鬆粉吸入劑中的沙美特囉和丙痠氟替卡鬆.採用C_(18)色譜柱,以甲醇-0.05 mol/L乙痠銨溶液(68:32)為流動相,檢測波長228 nm.沙美特囉和丙痠氟替卡鬆分彆在0.14～27.4 μg/ml和0.3～60μg/ml濃度範圍內線性關繫良好;迴收率為101.3%和101.5%.
건립료HPLC법측정사미특라체잡송분흡입제중적사미특라화병산불체잡송.채용C_(18)색보주,이갑순-0.05 mol/L을산안용액(68:32)위류동상,검측파장228 nm.사미특라화병산불체잡송분별재0.14～27.4 μg/ml화0.3～60μg/ml농도범위내선성관계량호;회수솔위101.3%화101.5%.
An HPLC method was established for the determination of salmeterol and fluticasone propionate in salmeterol xinafoate and fluticasone propionate powder for inhalation.A C_(18) column was used with the mobile phase of methanol-0.05 mol/L ammonium acetate(68:32)at detection wavelength of 228 nm.The calibration curves for salmeterol and fluticasone propionate were linear in the concentration ranges of 0.14-27.4 μg/ml and 0.3-60 μg/ml.The recoveries were 101.3%and 101.5%.
