CAJ | 학술논문

背景:动脉僵硬度是心血管疾病的独立危险因素.中心动脉反射波增强指数(augmentation index,Alx)是反映全身动脉僵硬度的重要指标.目的:研究新疆和田维吾尔族正常人群Alx,并进一步分析影响Alx的因素.方法:选取新疆和田地区559名维吾尔族正常人群(男251名,女308名),平均年龄(44.95±11.87)岁.所有研究对象均进行问卷调查、一般体格检查及血液生化检测,采用Sphygmocor脉搏波分析系统检测中心动脉收缩压及Alx.采用Pearson相关分析和偏相关分析进行两两相关分析,采用多元逐步回归分析Alx的影响因素.结果与结论:女性Alx值高于男性,且Alx与年龄呈正相关(男:r=0.548,女:r=0.405,P<0.05),在校正其他影响因素后,Alx与年龄仍呈正相关(男:r=0.182,女:r=0.234,P<0.05).多元逐步回归显示中心动脉收缩压、收缩压、性别、年龄、C-反应蛋白是新疆维吾尔族Alx的影响因素.中心动脉收缩压、收缩压、年龄、体质量、C-反应蛋白是男性Alx的影响因素;中心动脉收缩压、收缩压、年龄、身高、C-反应蛋白是女性Alx的影响因素.说明在新疆维吾尔族正常人群中,Alx女性高于男性,且与年龄相关,中心动脉收缩压、收缩压和C-反应蛋白也是新疆维吾尔族人群Alx的影响因素.
배경:동맥강경도시심혈관질병적독립위험인소.중심동맥반사파증강지수(augmentation index,Alx)시반영전신동맥강경도적중요지표.목적:연구신강화전유오이족정상인군Alx,병진일보분석영향Alx적인소.방법:선취신강화전지구559명유오이족정상인군(남251명,녀308명),평균년령(44.95±11.87)세.소유연구대상균진행문권조사、일반체격검사급혈액생화검측,채용Sphygmocor맥박파분석계통검측중심동맥수축압급Alx.채용Pearson상관분석화편상관분석진행량량상관분석,채용다원축보회귀분석Alx적영향인소.결과여결론:녀성Alx치고우남성,차Alx여년령정정상관(남:r=0.548,녀:r=0.405,P<0.05),재교정기타영향인소후,Alx여년령잉정정상관(남:r=0.182,녀:r=0.234,P<0.05).다원축보회귀현시중심동맥수축압、수축압、성별、년령、C-반응단백시신강유오이족Alx적영향인소.중심동맥수축압、수축압、년령、체질량、C-반응단백시남성Alx적영향인소;중심동맥수축압、수축압、년령、신고、C-반응단백시녀성Alx적영향인소.설명재신강유오이족정상인군중,Alx녀성고우남성,차여년령상관,중심동맥수축압、수축압화C-반응단백야시신강유오이족인군Alx적영향인소.
BACKGROUND:Arterial stiffness is an independent risk factor for cardiovascular disease.Augmentation index(Alx)is an important marker which reflects the systemic arterial stiffness.OBJECTIVE:To investigate Alx and the affecting factors in Xinjiang Uygur health adults.METHODS:A total of 559 healthy adults(251 males and 308 females)with a mean age of(44.95±11.87)years were selected from Hetian,Xinjiang Uygur Autonomous Region.The following indexes of all subjects were measured,including questionnaire,physical examination,blood biochemistry and C-reactive protein(CRP).Central systolic blood pressure(cSBP)and central Alx were measured by Sphygmocor.Pearson correlation and partial correlation analysis were used for two-group analysis of correlation,and multiple regression analysis was used to analyze influential factors for Alx.RESULTS AND CONCULUSION:Alx was greater in female than in male and was positively related to age in both sexes(male:r=0.548,female:r =0.405,P < 0.05),as well as adjusted other influential factors(male:r=0.182,female:r =0.234,P < 0.05).Multiple regression analysis showed that cSBP,systolic blood pressure(SBP),sex,age and CRP were main factors which affected Alx in Uygur healthy adults,cSBP,SBP,age,body mass and CRP were main factors which affected Alx in the male,while cSBP,SBP,age,height and CRP were main factors which affected Alx in the female.Results revealed that Alx was greater in female than in male which was positively related to age in both sexes.Age,cSBP,SBP and CRP were main factors that affected Alx in Xinjiang Uygur healthy adults.