CAJ | 학술논문

目的研究高胆固醇血症患者膳食脂肪摄入与血脂变化之间的关系.方法筛查739名志愿者后,纳入297例血清总胆固醇(TC)5.13 mmol/L的广州市民,随访6个月,采用连续3 d的24 h膳食回顾法及食用油种类及用量记录表调查研究对象膳食摄入情况,并测定研究对象在研究起始和结束时的血脂水平,分析不同膳食脂肪供能比及脂肪酸供能比与血脂变化的关系.结果纳入研究对象297例,其中281例(男88例,女193例)完成6个月的研究,研究起始时对象的TC为(6.09±0.68)mmot/L.将研究对象按照总脂供能比,分为<25%(90例),25%～30%(97例),30%(94例)3组,总脂供能比≤30%的Ⅰ组及Ⅱ组TC、低密度脂蛋白胆固醇(LDL-C)降低率大于总脂供能比30%的Ⅲ组.将研究对象按照饱和脂肪酸(SFA)供能比分为<7%(81例),7%～10%(129例),10%(71例)3组,SFA供能比≤10%的Ⅰ组和Ⅱ组TC、LDL-C降低率大于SFA供能比10%的Ⅲ组.将研究对象按照单不饱和脂肪酸(MUFA)供能比分为<10%(93例),10%～13%(106例),13%(82例)3组,MUFA供能比为10%～13%的Ⅱ组,代和LDL-C降低率大于另外两组.将研究对象按照多不饱和脂肪酸(PUFA)供能比分为<7%(88例),7%～9%(94例),9%(99例)3组,未发现3组间血脂降低率差异有统计学意义.结论对于血脂异常患者,总脂供能比≤30%,SFA供能比≤10%,MUFA供能比在10%～13%的范围有利于改善其血脂水平.
목적 연구고담고순혈증환자선식지방섭입여혈지변화지간적관계.방법 사사739명지원자후,납입297례혈청총담고순(TC)5.13 mmol/L적엄주시민,수방6개월,채용련속3 d적24 h선식회고법급식용유충류급용량기록표조사연구대상선식섭입정황,병측정연구대상재연구기시화결속시적혈지수평,분석불동선식지방공능비급지방산공능비여혈지변화적관계.결과 납입연구대상297례,기중281례(남88례,녀193례)완성6개월적연구,연구기시시대상적TC위(6.09±0.68)mmot/L.장연구대상안조총지공능비,분위<25%(90례),25%～30%(97례),30%(94례)3조,총지공능비≤30%적Ⅰ조급Ⅱ조TC、저밀도지단백담고순(LDL-C)강저솔대우총지공능비30%적Ⅲ조.장연구대상안조포화지방산(SFA)공능비분위<7%(81례),7%～10%(129례),10%(71례)3조,SFA공능비≤10%적Ⅰ조화Ⅱ조TC、LDL-C강저솔대우SFA공능비10%적Ⅲ조.장연구대상안조단불포화지방산(MUFA)공능비분위<10%(93례),10%～13%(106례),13%(82례)3조,MUFA공능비위10%～13%적Ⅱ조,대화LDL-C강저솔대우령외량조.장연구대상안조다불포화지방산(PUFA)공능비분위<7%(88례),7%～9%(94례),9%(99례)3조,미발현3조간혈지강저솔차이유통계학의의.결론 대우혈지이상환자,총지공능비≤30%,SFA공능비≤10%,MUFA공능비재10%～13%적범위유리우개선기혈지수평.
Objective To study the effects of dietary fatty acids on the serum lipids in hyperoholestorolemic subjects. Methods All 297 residents with hypercholesterolemia were enrolled in Guangzhou. The dietary composition and the changes in serum lipid levels during the 6-month follow-up were analyzed. Results (1) 297 subjects were enrolled and 281 subjects (88 male, 193 female) completed the 6-month follow-up. The serum TC concentration of the subjects was (6. 09±0. 68) mmoL/L at baseline. (2) According to the percentage of energy from total fat, all of the subjects were divided into three groups, including total fat % en <25%( group Ⅰ, 90 subjects),25% -30% ( group Ⅱ, 97 subjects), 30% ( group Ⅲ, 94 subjects). The reduction of TC and LDL-C in group Ⅰ and group Ⅱ was greater than that in group Ⅲ. (3) According to the percentage of energy from SFA, all of the subjects were divided into three groups, including SFA % en < 7% ( groupⅠ, 81 subjects), 7% - 10% ( group Ⅱ, 129 subjects), 10% ( group Ⅲ, 71 subjects). The reduction Of TC and LDL-C in group Ⅰ and group Ⅱ was greater than that in group Ⅲ. (4) All of the subjects were divided into three groups, according to the percentage of energy from MUFA, including MUFA % en < 10% (group Ⅰ , 93 subjects), 10% - 13% ( group Ⅱ , 106 subjects), 13% ( group Ⅲ, 82 subjects). The reduction of TC and LDL-C in group Ⅱwas greater than that in group Ⅰ and group Ⅲ. ( 5 ) All of the subjects were divided into three groups according to the percentage of energy from PUFA, including PUFA % en <7% (88 subjects),7% -9% (94 subjects), 9% (99 subjects). No significant difference was found among the reduction of serum lipids in the three groups. Conclusion Dietary total fat % en ≤30%, SFAs % en ≤10% and MUFAs % en 10% - 13% should be conductive to reduce the serum lipids of patients with hyperlipidemia.