CAJ | 학술논문

目的探讨影响结直肠癌预后的因素在预测结直肠癌术后生存中的价值.方法应用多因素回归的分析方法,回顾性分析有完整临床病理资料和随访资料的941例结直肠癌患者的临床特点、病理特征及其对预后的影响.结果结直肠癌患者总的3,5年生存率分别为63.2%和60.8%,中位生存时间为1841d.单因素分析显示,其预后与肿瘤的大体分型、侵袭程度、转移情况、分化等级、病理分期以及癌性肠梗阻均有相关性.应用Cox比例危险回归模型分析,则显示肿瘤的大体分型、分化程度、肠壁的侵袭深度和病理分期是影响结直肠癌患者术后生存的独立因素.结论病理分期是影响结直肠癌预后最重要的一个指标(P＜0.0005),对于指导手术治疗、术后辅助治疗和判断预后方面具有重要作用.
목적탐토영향결직장암예후적인소재예측결직장암술후생존중적개치.방법응용다인소회귀적분석방법,회고성분석유완정림상병리자료화수방자료적941례결직장암환자적림상특점、병리특정급기대예후적영향.결과결직장암환자총적3,5년생존솔분별위63.2%화60.8%,중위생존시간위1841d.단인소분석현시,기예후여종류적대체분형、침습정도、전이정황、분화등급、병리분기이급암성장경조균유상관성.응용Cox비례위험회귀모형분석,칙현시종류적대체분형、분화정도、장벽적침습심도화병리분기시영향결직장암환자술후생존적독립인소.결론병리분기시영향결직장암예후최중요적일개지표(P＜0.0005),대우지도수술치료、술후보조치료화판단예후방면구유중요작용.
Objective: To evaluate the relationship between clinicopathologic features and prognosis of col-orectal cancer after surgical treatment. Methods: The relationship between clinicopathological character-istics and prognosis of 941 patients with colorectal cancer after surgical treatment were investigated byunivariate and multivariate analysis. Results: The overall 3- and 5-year survival rates of patients withcolorectal cancer after surgical treatment were 63.2% and 60.8% respectively with a median survival of1841 days. Univariate analysis revealed that such factors as gross findings, degree of differentiation, depthof infiltration, nodal and distant metastasis and neoplastic intestinal obstruction were correlated with thesurvival rate. Dukes stages, gross tumor configuration, intramural spread and differentiation degree wereshown to be available independent prognostic factors by multivariate analysis. Conclusion: Dukes stage,as the most important available independent prognostic factor for colorectal cancer (P＜0.0005), can beused to assess the postoperative survival.