安徽农业科学
安徽農業科學
안휘농업과학
JOURNAL OF ANHUI AGRICULTURAL SCIENCES
2010年
3期
1252-1253,1255
,共3页
张铁%王春光%吕建存%倪耀娣
張鐵%王春光%呂建存%倪耀娣
장철%왕춘광%려건존%예요제
硝酸铈%小鼠%外周血白细胞总数%碳粒廓清率%脾指数%胸腺指数
硝痠鈰%小鼠%外週血白細胞總數%碳粒廓清率%脾指數%胸腺指數
초산시%소서%외주혈백세포총수%탄립곽청솔%비지수%흉선지수
Cerium nitrate%Mice%Peripheral WBC count%Carbon granular clearance%Spleen index%Thymus index
[目的]探讨稀土元素对动物非特异性免疫功能的影响机制及其有效剂量.[方法]将试验小鼠随机平均分为4组,分别饲喂蒸馏水和低(2 mg/kg)、中(20 mg/kg)、高(200 mg/kg)剂量的硝酸铈溶液,50 d后测定和比较其免疫指标.[结果]对照组和低、中、高剂量组小鼠的外周血白细胞总数分别为(5.60±1.13)×10~9、(7.20±1.36)×10~9、(9.42±2.48)×10~9和(8.62±2.72)×10~9/L,表明硝酸铈可提高小鼠的外周血白细胞总数.4组小鼠的校正廓清指数分别为6.167 4±0.256 8、5.557 3±0.184 3、10.210 6±2.084 6和9.237 3±1.918 7,表明硝酸铈可提高小鼠的碳粒廓清指数.4组小鼠的脾指数为3.074 3±0.319 2、4.275 4±1.400 2、4.907 8±1.342 3和3.655 9±1.150 8,胸腺指数分别为2.217 8±0.815 6、2.341 4±1.026 7、3.695 3±0.582 1和2.868 3±0.707 3,表明硝酸铈可提高小鼠的脾指数和胸腺指数.[结论]口服硝酸铈可显著提高小鼠的非特异性免疫力,以中等剂量的效果最为显著.
[目的]探討稀土元素對動物非特異性免疫功能的影響機製及其有效劑量.[方法]將試驗小鼠隨機平均分為4組,分彆飼餵蒸餾水和低(2 mg/kg)、中(20 mg/kg)、高(200 mg/kg)劑量的硝痠鈰溶液,50 d後測定和比較其免疫指標.[結果]對照組和低、中、高劑量組小鼠的外週血白細胞總數分彆為(5.60±1.13)×10~9、(7.20±1.36)×10~9、(9.42±2.48)×10~9和(8.62±2.72)×10~9/L,錶明硝痠鈰可提高小鼠的外週血白細胞總數.4組小鼠的校正廓清指數分彆為6.167 4±0.256 8、5.557 3±0.184 3、10.210 6±2.084 6和9.237 3±1.918 7,錶明硝痠鈰可提高小鼠的碳粒廓清指數.4組小鼠的脾指數為3.074 3±0.319 2、4.275 4±1.400 2、4.907 8±1.342 3和3.655 9±1.150 8,胸腺指數分彆為2.217 8±0.815 6、2.341 4±1.026 7、3.695 3±0.582 1和2.868 3±0.707 3,錶明硝痠鈰可提高小鼠的脾指數和胸腺指數.[結論]口服硝痠鈰可顯著提高小鼠的非特異性免疫力,以中等劑量的效果最為顯著.
[목적]탐토희토원소대동물비특이성면역공능적영향궤제급기유효제량.[방법]장시험소서수궤평균분위4조,분별사위증류수화저(2 mg/kg)、중(20 mg/kg)、고(200 mg/kg)제량적초산시용액,50 d후측정화비교기면역지표.[결과]대조조화저、중、고제량조소서적외주혈백세포총수분별위(5.60±1.13)×10~9、(7.20±1.36)×10~9、(9.42±2.48)×10~9화(8.62±2.72)×10~9/L,표명초산시가제고소서적외주혈백세포총수.4조소서적교정곽청지수분별위6.167 4±0.256 8、5.557 3±0.184 3、10.210 6±2.084 6화9.237 3±1.918 7,표명초산시가제고소서적탄립곽청지수.4조소서적비지수위3.074 3±0.319 2、4.275 4±1.400 2、4.907 8±1.342 3화3.655 9±1.150 8,흉선지수분별위2.217 8±0.815 6、2.341 4±1.026 7、3.695 3±0.582 1화2.868 3±0.707 3,표명초산시가제고소서적비지수화흉선지수.[결론]구복초산시가현저제고소서적비특이성면역력,이중등제량적효과최위현저.
[Objective] The research aimed to discuss the influencing mechanism of a rare-earth element on the non-specific immune function of animals and its effective dose. [Method] The tested mice were divided into 4 groups randomly and averagely, they were fed with distilled water and low-(2 mg/kg), middle-(20 mg/kg) and high-dose(200 mg/kg) cerium nitrate solutions resp. After 50 d, their immune indices were determined and compared. [Result] The peripheral WBC counts of mice in control group and low-, middle- and high-dose groups were (5.60±1.13)×10~9, (7.20±1.36)×10~9, (9.42±2.48)×10~9 and (8.62±2.72)×10~9/L resp., showing that the cerium nitrate could enhance the peripheral WBC count of mice. The corrected clearance indices of mice in those 4 groups were 6.167 4±0.256 8, 5.557 3±0.184 3, 10.210 6±2.084 6 and 9.237 3±1.918 7 resp., showing that the cerium nitrate could enhance the carbon clearance index of mice. The spleen indices of mice in those 4 groups were 3.074 3±0.319 2, 4.275 4±1.400 2, 4.907 8±1.342 3 and 3.655 9±1.150 8 resp. and their thymus indices were 2.217 8±0.815 6, 2.341 4±1.026 7, 3.695 3±0.582 1 and 2.868 3±0.707 3 resp., showing that the cerium nitrate could enhance the spleen index and thymus index of mice. [Conclusion] The oral cerium nitrate could enhance the non-specific immunity of mice significantly and the effect of middle-dose was most significant.
