CAJ | 학술논문

目的探讨米非司酮与孕三烯酮用于子宫内膜异位症术后的临床疗效及安全性.方法对120例子宫内膜异位症患者进行回顾性分析,随机分为三组,术后应用米非司酮组、术后应用孕三烯酮组以及未用药组各40例.比较三组临床疗效、药物不良反应以及复发情况.结果米非司酮组患者40例,其中有6例复发,2例在术后1年内复发,3例在术后1～3年内复发.1例在3年后复发.孕三烯酮组患者40例.其中有5例复发,2例在术后1年内复发,2例在术后1-3年内复发,1例在3年后复发.未用药组患者40例,其中有12例复发,4例在术后1年内复发,4例在术后1-3年内复发,3例在3年后复发.对米非司酮组、孕三烯酮组进行疗效比较后发现差异无显著性(P＞0.05).米非司酮组、孕三烯酮组复发率分别为15%、12.5%,低于未用药组的(30%),差异均具有显著性(P＜0,05).结论米非司酮与孕三烯酮用于子宫内膜异位症术后具有经济实用、安全、有效、不良反应少等特点,能显著降低其复发,是治疗子宫内膜异位症术后患者的有效方法.
목적 탐토미비사동여잉삼희동용우자궁내막이위증술후적림상료효급안전성.방법 대120례자궁내막이위증환자진행회고성분석,수궤분위삼조,술후응용미비사동조、술후응용잉삼희동조이급미용약조각40례.비교삼조림상료효、약물불량반응이급복발정황.결과 미비사동조환자40례,기중유6례복발,2례재술후1년내복발,3례재술후1～3년내복발.1례재3년후복발.잉삼희동조환자40례.기중유5례복발,2례재술후1년내복발,2례재술후1-3년내복발,1례재3년후복발.미용약조환자40례,기중유12례복발,4례재술후1년내복발,4례재술후1-3년내복발,3례재3년후복발.대미비사동조、잉삼희동조진행료효비교후발현차이무현저성(P＞0.05).미비사동조、잉삼희동조복발솔분별위15%、12.5%,저우미용약조적(30%),차이균구유현저성(P＜0,05).결론 미비사동여잉삼희동용우자궁내막이위증술후구유경제실용、안전、유효、불량반응소등특점,능현저강저기복발,시치료자궁내막이위증술후환자적유효방법.
Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,