CAJ | 학술논문

目的探讨COPD急性加重期(AECOPD)患者血浆白介素(IL)-10、IL-13浓度与临床治疗效果之间的关系.方法 36例AECOPD住院治疗患者被纳入研究,用酶联免疫吸附试验检测患者入院时的血浆IL-10和IL-13浓度,对患者的临床表现进行量化评分,根据患者入院时、治疗48h、治疗96 h的临床表现积分结合肺通气功能指标对治疗效果进行评价,分析IL-10、IL-13浓度与治疗效果之间的关系.结果 IL-10浓度与治疗48 h临床表现积分降低值和肺通气功能改善值的相关系数分别为0.85和0.48,与治疗96 h临床表现积分降低值和肺通气功能改善值的相关系数分别为0.64和0.52;IL-13浓度与治疗48 h临床表现积分降低值和肺通气功能改善值的相关系数分别为-0.41和-0.34,与治疗96h临床表现积分降低值的相关系数为-0.36;以上相关系数均具有统计学意义(P＜0.05).结论血浆IL-10浓度与AECOPD治疗效果呈正相关而IL-13浓度与治疗效果呈负相关.
목적 탐토COPD급성가중기(AECOPD)환자혈장백개소(IL)-10、IL-13농도여림상치료효과지간적관계.방법 36례AECOPD주원치료환자피납입연구,용매련면역흡부시험검측환자입원시적혈장IL-10화IL-13농도,대환자적림상표현진행양화평분,근거환자입원시、치료48h、치료96 h적림상표현적분결합폐통기공능지표대치료효과진행평개,분석IL-10、IL-13농도여치료효과지간적관계.결과 IL-10농도여치료48 h림상표현적분강저치화폐통기공능개선치적상관계수분별위0.85화0.48,여치료96 h림상표현적분강저치화폐통기공능개선치적상관계수분별위0.64화0.52;IL-13농도여치료48 h림상표현적분강저치화폐통기공능개선치적상관계수분별위-0.41화-0.34,여치료96h림상표현적분강저치적상관계수위-0.36;이상상관계수균구유통계학의의(P＜0.05).결론 혈장IL-10농도여AECOPD치료효과정정상관이IL-13농도여치료효과정부상관.
Objective To investigate the relationship among the concentration of plasma interleukin (IL)-10 and plasma IL-13 and the clinical therapeutic effect in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Thirty-six AECOPD inpatients were enrolled in this study.Blood samples of the subjects were collected as soon as hospitalization, and plasma IL-10 and IL-13concentrations were analyzed by enzyme-linked immunosorbent assay.The clinical manifestations of subjects were quantified by a special designed score standard, and were evaluated at the time points of hospitalization, 48 hours treatment and 96 hours treatment.The therapeutic effect was evaluated by clinical manifestations score combined with pulmonary ventilation functional parameter.Eventually, the correlation among the concentration of IL-10 concentration and IL-13 and the clinical therapeutic effect were analyzed.Results The correlation coefficients between clinical manifestations score decrease and pulmonary ventilation function improvement with plasma IL-10 concentration after 48 hours treatment were 0.85 and 0.48 respectively,then, 0.64 and 0.52 after 96 hours treatment.The correlation coefficients between clinical manifestations score decrease and pulmonary ventilation function improvement with plasma IL-13 concentration after 48hours treatment were -0.41 and -0.34, after 96 hours treatment , correlation coefficients between clinical manifestations score decrease with plasma IL-13 concentration was -0.36.All of the above correlation coefficients were statistically significant.Conclusion Plasma IL-10 concentration was positively, whereas, IL-13 concentration was negatively correlated with the therapeutic effect in AECOPD patients.