CAJ | 학술논문

目的探讨阿魏酸钠对特发性肺纤维化患者血清结缔组织生长因子(CTGF)、基质金属蛋白酶-9(MMP-9)、组织抑制物-1(TIMP-1)的影响.方法 46例特发性肺纤维化患者随机分为对照组20例给予常规治疗;治疗组26例在常规治疗基础上加用阿魏酸钠.治疗前后检测血清CTGF、MMP-9、TIMP-1.结果治疗组治疗后CTGF、MMP-9、TIMP-1均有明显改善,与对照组比较差异有统计学意义(P<0.05).结论阿魏酸钠可能通过改善血清CTGF、MMP-9、TIMP-1水平而改善特发性肺纤维化患者的病情.
목적 탐토아위산납대특발성폐섬유화환자혈청결체조직생장인자(CTGF)、기질금속단백매-9(MMP-9)、조직억제물-1(TIMP-1)적영향.방법 46례특발성폐섬유화환자수궤분위대조조20례급여상규치료;치료조26례재상규치료기출상가용아위산납.치료전후검측혈청CTGF、MMP-9、TIMP-1.결과 치료조치료후CTGF、MMP-9、TIMP-1균유명현개선,여대조조비교차이유통계학의의(P<0.05).결론 아위산납가능통과개선혈청CTGF、MMP-9、TIMP-1수평이개선특발성폐섬유화환자적병정.
Objective To explore the effects of sodium ferulate injection on CTGF, MMP-9 and TIMP-I in the serum of the patients with idiopathic pulmonary fibrosis(IPF). Methods 46 cases with IPF were randomly divid-ed into control group of 20 eases and treatment group of 26 cases. Control group was given the usual treatment and the treatment group was given the usual treatment and sodium ferulate injection. The levels of CTGF, MMP-9 and TIMP-1 in the serum were measured before and after treatment. Results After treatment,the concentration of CTGF,MMP-9 and TIMP-1 in patients in the treatment group was significantly improved than that in the control group(P < 0.05). Conclusion The treatment with sodium ferulate injection could improve the IPF through improving the production of CTGF,MMP-9 and TIMP-1.