中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
6期
603-605
,共3页
李霞%栾树荣%耿秀英%刘晓丽%李静
李霞%欒樹榮%耿秀英%劉曉麗%李靜
리하%란수영%경수영%류효려%리정
Graves病%白细胞介素-6
Graves病%白細胞介素-6
Graves병%백세포개소-6
Grave disease%Interleukin-6
目的 探讨血清白细胞介素-6(IL-6)测定在Graves病患者中的临床意义.方法 用ELISA法测定75例Graves病患者的IL-6,分析IL-6与其他功能指标(如T3、T4等)、免疫指标(如TRAb)的相关性,并与健康对照组比较.结果 IL-6水平Graves病组为(1.84 ±1.58)ns/L,健康对照组为(1.28 ±0.46)ng/L,2组比较差异有统计学意义(t=2.55,P<0.05).相关分析发现,IL-6与T3(r=0.55)、T4(r=0.40)、FT4(r=0.36)、FT3(r=0.35)及TRAb(r=0.47)正相关(P均<0.05),与TSH负相关(r=0.58,P<0.05).结论 IL-6可以作为Graves病的免疫紊乱及甲状腺功能的良好评价指标.
目的 探討血清白細胞介素-6(IL-6)測定在Graves病患者中的臨床意義.方法 用ELISA法測定75例Graves病患者的IL-6,分析IL-6與其他功能指標(如T3、T4等)、免疫指標(如TRAb)的相關性,併與健康對照組比較.結果 IL-6水平Graves病組為(1.84 ±1.58)ns/L,健康對照組為(1.28 ±0.46)ng/L,2組比較差異有統計學意義(t=2.55,P<0.05).相關分析髮現,IL-6與T3(r=0.55)、T4(r=0.40)、FT4(r=0.36)、FT3(r=0.35)及TRAb(r=0.47)正相關(P均<0.05),與TSH負相關(r=0.58,P<0.05).結論 IL-6可以作為Graves病的免疫紊亂及甲狀腺功能的良好評價指標.
목적 탐토혈청백세포개소-6(IL-6)측정재Graves병환자중적림상의의.방법 용ELISA법측정75례Graves병환자적IL-6,분석IL-6여기타공능지표(여T3、T4등)、면역지표(여TRAb)적상관성,병여건강대조조비교.결과 IL-6수평Graves병조위(1.84 ±1.58)ns/L,건강대조조위(1.28 ±0.46)ng/L,2조비교차이유통계학의의(t=2.55,P<0.05).상관분석발현,IL-6여T3(r=0.55)、T4(r=0.40)、FT4(r=0.36)、FT3(r=0.35)급TRAb(r=0.47)정상관(P균<0.05),여TSH부상관(r=0.58,P<0.05).결론 IL-6가이작위Graves병적면역문란급갑상선공능적량호평개지표.
Objective To study the clinical value of serum FL-6 detection in patients with Graves. Methods The level of IL-6 was detected in 75 Graves patients and controls with ELISA, the correlation between IL-6, other function parameter (T3, T4, etc.) and immune indicators (TRAb) were analyzed. Results The level of IL-6 in Graves patients was(1. 84 ±1. 58) ng/L, which was significantly higher than the healthy controls(l. 28 ±0.46)ng/L (t=2.55,P<0.05).IL-6 was positive correlation with T3(r =0. 55) ,T4(r =0. 40) ,FT4(r =0. 36) , FT3(r = 0. 35)and TRAb(r = 0. 47) (P <0. 05)and was negative correlation with TSH(r= -0. 58, P < 0. 05). Conclusions IL-6 can be used as a good index of immune derangement and thyroid function disorders in Grave patients.
