CAJ | 학술논문

目的探讨染色体核型分析在骨髓增生异常综合征(MDS)诊断、预后评估中的价值.方法采用骨髓短期培养法和R显带技术对58例MDS患者进行染色体核型分析,同时追踪其临床病情进展情况.结果 58例MDS患者中有31例(53.4%)检出异常克隆.在异常染色体核型中+8和高度复杂异常最多.58例患者经追踪观察,19例(30.5%)患者转化为急性白血病.结论染色体核型分析在MDS诊断预后评估方面具有重要价值.
목적탐토염색체핵형분석재골수증생이상종합정(MDS)진단、예후평고중적개치.방법채용골수단기배양법화R현대기술대58례MDS환자진행염색체핵형분석,동시추종기림상병정진전정황.결과 58례MDS환자중유31례(53.4%)검출이상극륭.재이상염색체핵형중+8화고도복잡이상최다.58례환자경추종관찰,19례(30.5%)환자전화위급성백혈병.결론염색체핵형분석재MDS진단예후평고방면구유중요개치.
Objective To explore theralue of karyotype analysis in MDS for diagnosis, cure and progno-sis. Methods Chromosome analysis was performed in 58 cases of MDS using the short-term culture of bone marrow eell and R-banding technique, meanwhile,their clinical progress was followed up. Results Karyotype a-nalysis showed that 31 eases(53.4%) had elonal Karyotypie abnormalities. The nost common chromosomal ab-errations included +8 and high complex karyotypic, and then-7/7q-In the following up, 19 eases (30.5%) transformed into acute leukemia. Conclusion The Karyotype analysis is very important for diagnosis, cure and prognosis of MDS.