CAJ | 학술논문

目的观察西洛他唑联合缬沙坦对早期糖尿病肾病患者血清同型半胱氨酸及胱抑素C的影响.方法 96例早期糖尿病肾病患者按随机数字表法分为两组,观察组48例采用西洛他唑联合缬沙坦治疗,对照组仅采用缬沙坦治疗,比较两组的疗效,治疗前后24h尿微量白蛋白以及血清同型半胱氨酸、胱抑素C水平变化.结果观察组总有效率为85.4％(41/48),明显高于对照组的66.7％( 32/48),差异有统计学意义(P＜0.05).观察组和对照组治疗3周后24 h尿微量白蛋白、血清同型半胱氨酸和胱抑素C水平分别为( 125.48±13.76)mg、(9.25±3.52)μmol/L、(7.82±2.14) mg/L和(168.38±15.43) mg、(13.72±4.23)μmol/L、(9.57±2.85) mg/L,均较治疗前的(279.31±21.52)mg、(18.52±6.14)μmol/L、( 13.25±3.79) mg/L和(275.24±19.31)mg、(18.48±6.12)μmol/L、(13.19±3.76) mg/L明显下降,差异有统计学意义(P＜0.05).并且,观察组治疗3周后24h尿微量白蛋白、血清同型半胱氨酸和胱抑素C水平明显低于同期对照组,差异有统计学意义(P＜0.05).结论西洛他唑联合缬沙坦对早期糖尿病肾病患者进行治疗,能够明显提高疗效,降低尿微量白蛋白、血清同型半胱氨酸和胱抑素C水平,值得临床推广应用.
목적 관찰서락타서연합힐사탄대조기당뇨병신병환자혈청동형반광안산급광억소C적영향.방법 96례조기당뇨병신병환자안수궤수자표법분위량조,관찰조48례채용서락타서연합힐사탄치료,대조조부채용힐사탄치료,비교량조적료효,치료전후24h뇨미량백단백이급혈청동형반광안산、광억소C수평변화.결과 관찰조총유효솔위85.4％(41/48),명현고우대조조적66.7％( 32/48),차이유통계학의의(P＜0.05).관찰조화대조조치료3주후24 h뇨미량백단백、혈청동형반광안산화광억소C수평분별위( 125.48±13.76)mg、(9.25±3.52)μmol/L、(7.82±2.14) mg/L화(168.38±15.43) mg、(13.72±4.23)μmol/L、(9.57±2.85) mg/L,균교치료전적(279.31±21.52)mg、(18.52±6.14)μmol/L、( 13.25±3.79) mg/L화(275.24±19.31)mg、(18.48±6.12)μmol/L、(13.19±3.76) mg/L명현하강,차이유통계학의의(P＜0.05).병차,관찰조치료3주후24h뇨미량백단백、혈청동형반광안산화광억소C수평명현저우동기대조조,차이유통계학의의(P＜0.05).결론 서락타서연합힐사탄대조기당뇨병신병환자진행치료,능구명현제고료효,강저뇨미량백단백、혈청동형반광안산화광억소C수평,치득림상추엄응용.
Objective To observe the affection of cilostazol combined with valsartan in treating patients with early diabetic nephropathy on serum homocysteine and cystatin C,Methods Ninety-six cases with early diabetic nephropathy were divided into two groups by random digits table method with 48 cases each:observation group was treated with cilostazol and valsartan,control group was treated with valsartan alone.The effect and the levels of 24 h urinary albumin,serum homocysteine and cystatin C before and after treatment in two groups were compared.Results The total effective rate in observation group [85.4％(41/48) ] was significantly higher than that in control group [66.7％(32/48) ](P ＜ 0.05 ).The levels of 24 h urinary albumin,serum homocysteine and cystatin C were significantly decreased after treatment of three weeks in observation group and control group [ (125.48±13.76) mg,(9.25±3.52)p mol/L,(7.82±2.14) mg/L and (168.38±15.43) mg,(13.72±4.23) μ mol/L,(9.57±2.85) mg/L vs.(279.31±21.52) mg,(18.52±6.14) μ mol/L,( 13.25±3.79) mg/L and (275.24±19.31 ) mg,( 18.48±6.12) μ mol/L,( 13.19±3.76)mg/L](P＜ 0.05).And the levels of 24 h urinary albumin,serum homocysteine and cystatin C after treatment of three weeks in observation group were obviously lower than those in control group(P ＜ 0.05).Conclusions Cilostazol combined with valsartan in treating patients with early diabetic nephropathy can improve clinical effect obviously,degrade the level of urinary albumin,homocysteine and cystatin C.Therefore,it deserves to be applied in clinic.