中原医刊
中原醫刊
중원의간
CENTRAL PLAINS MEDICAL JOURNAL
2008年
2期
5-7
,共3页
何东华%李继广%刘涛%叶继峰%董清
何東華%李繼廣%劉濤%葉繼峰%董清
하동화%리계엄%류도%협계봉%동청
吡格列酮%糖耐量减低%非酒精性脂肪肝%脂联素%胰岛素抵抗
吡格列酮%糖耐量減低%非酒精性脂肪肝%脂聯素%胰島素牴抗
필격렬동%당내량감저%비주정성지방간%지련소%이도소저항
Pioglitazone%Impaired glucose tolerance%Non - alcoholic fatty liver%Adiponerctin%Insulin re-sistance
目的 探讨吡格列酮对糖耐量减低合并非酒精性脂肪肝患者血清脂联素变化的影响.方法 吡格列酮组46例糖耐量减低合并非酒精性脂肪肝患者,在饮食、运动治疗的基础上,于早餐前15 min 口服吡格列酮30 mg/d.治疗16周后进行分析比较血清脂联素水平变化,治疗前后比较用配对t检验,治疗后组间比较用独立样本t检验.结果 糖耐量减低合并非酒精性脂肪肝患者采用吡格列酮治疗 16 周后与治疗前相比血清脂联素水平明显升高(t=9.14.P<0.01),胰岛素抵抗指数明显下降(t=5.10,P<0.01);吡格列酮组与对照组治疗16周后相比血清脂联素水平升高明显(t=7.63,P<0.01),胰岛素抵抗指数明显下降(t=5.37,P<0.01).结论 吡格列酮治疗后,糖耐量减低合并非酒精性脂肪肝患者血清脂联素水平明显升高,改善了胰岛素的敏感性,降低了胰岛素抵抗.
目的 探討吡格列酮對糖耐量減低閤併非酒精性脂肪肝患者血清脂聯素變化的影響.方法 吡格列酮組46例糖耐量減低閤併非酒精性脂肪肝患者,在飲食、運動治療的基礎上,于早餐前15 min 口服吡格列酮30 mg/d.治療16週後進行分析比較血清脂聯素水平變化,治療前後比較用配對t檢驗,治療後組間比較用獨立樣本t檢驗.結果 糖耐量減低閤併非酒精性脂肪肝患者採用吡格列酮治療 16 週後與治療前相比血清脂聯素水平明顯升高(t=9.14.P<0.01),胰島素牴抗指數明顯下降(t=5.10,P<0.01);吡格列酮組與對照組治療16週後相比血清脂聯素水平升高明顯(t=7.63,P<0.01),胰島素牴抗指數明顯下降(t=5.37,P<0.01).結論 吡格列酮治療後,糖耐量減低閤併非酒精性脂肪肝患者血清脂聯素水平明顯升高,改善瞭胰島素的敏感性,降低瞭胰島素牴抗.
목적 탐토필격렬동대당내량감저합병비주정성지방간환자혈청지련소변화적영향.방법 필격렬동조46례당내량감저합병비주정성지방간환자,재음식、운동치료적기출상,우조찬전15 min 구복필격렬동30 mg/d.치료16주후진행분석비교혈청지련소수평변화,치료전후비교용배대t검험,치료후조간비교용독립양본t검험.결과 당내량감저합병비주정성지방간환자채용필격렬동치료 16 주후여치료전상비혈청지련소수평명현승고(t=9.14.P<0.01),이도소저항지수명현하강(t=5.10,P<0.01);필격렬동조여대조조치료16주후상비혈청지련소수평승고명현(t=7.63,P<0.01),이도소저항지수명현하강(t=5.37,P<0.01).결론 필격렬동치료후,당내량감저합병비주정성지방간환자혈청지련소수평명현승고,개선료이도소적민감성,강저료이도소저항.
Objective To study the effect of pioglitazone on serum adiponerctin levels in patients with impaired glucose tolerance combined with non - alcoholic fatty liver. Methods On the basis of dietotherapy and kinetotherapy,the 46 cases took pioglitazone(30 mg/d)15 minutes before breakfast for 16 weeks. Before and after the treatment of pioglitazone, the levels of serum adiponerctin were determined to compare. Then made a-nalysis of paired samples t - test for the before and after treatment, and made analysis of independent sample t-test for the treatment group. Results There was distinct rise on serum adiponerctin levels in the patients with impaired glucose tolerance and non - alcoholic fatty liver after treatment with pioglitazone for 16 weeks (t = 9.14, P <0.01 ),and distinct decline of the index of insulin sensitivity(t = 5.10. P <0.01). Con-tract with the control group, there was distinct rise of the serum adiponectin levels in pioglitazone group after treatment for 16 weeks(t =7.63, P <0.01) ,and distinct decline of the index of insulin sensitivity(t =5.37, P < 0.01). Conclusion After treatment with pioglitazone, the levels of serum adiponerctin rose dis-tinctly in patients with impaired glucose tolerance combined with non -alcoholic fatty liver. It improved the in-sulin sensitivity and reduce the insulin resistance.
