中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
13期
8-9
,共2页
精神分裂症%抑郁%焦虑%抗抑郁药%西酞普兰
精神分裂癥%抑鬱%焦慮%抗抑鬱藥%西酞普蘭
정신분렬증%억욱%초필%항억욱약%서태보란
Schizophrenia%Depression%Anxiety%Anti - depression drug%Citalopram
目的 探讨抗抑郁药西酞普兰对精神分裂症后抑郁的辅助治疗作用及安全性.方法 对符合CC-MD-3关于精神分裂症的诊断且好转后伴焦虑抑郁症状的住院患者进行随机分组,研究组(78例)给予抗精神病药加抗抑郁药(西酞普兰20 mg/d)治疗;对照组(77例)单给抗精神病药治疗;两组于入组时、2周末、4周末分别评定抑郁自评量表(SDS)和焦虑自评量表(SAS),以副反应量表(TESS)评定其安全性,然后进行比较.结果 两组的SDS和SAS总分在治疗后均显著下降(P<0.05或<0.01);研究组2周末和4周末的疗效显著优于对照组(P<0.05或<0.01);两组的不良反应比较差异无统计学意义(P>0.05).结论 抗抑郁药西酞普兰对精神分裂症后抑郁有辅助治疗作用,不良反应轻微.
目的 探討抗抑鬱藥西酞普蘭對精神分裂癥後抑鬱的輔助治療作用及安全性.方法 對符閤CC-MD-3關于精神分裂癥的診斷且好轉後伴焦慮抑鬱癥狀的住院患者進行隨機分組,研究組(78例)給予抗精神病藥加抗抑鬱藥(西酞普蘭20 mg/d)治療;對照組(77例)單給抗精神病藥治療;兩組于入組時、2週末、4週末分彆評定抑鬱自評量錶(SDS)和焦慮自評量錶(SAS),以副反應量錶(TESS)評定其安全性,然後進行比較.結果 兩組的SDS和SAS總分在治療後均顯著下降(P<0.05或<0.01);研究組2週末和4週末的療效顯著優于對照組(P<0.05或<0.01);兩組的不良反應比較差異無統計學意義(P>0.05).結論 抗抑鬱藥西酞普蘭對精神分裂癥後抑鬱有輔助治療作用,不良反應輕微.
목적 탐토항억욱약서태보란대정신분렬증후억욱적보조치료작용급안전성.방법 대부합CC-MD-3관우정신분렬증적진단차호전후반초필억욱증상적주원환자진행수궤분조,연구조(78례)급여항정신병약가항억욱약(서태보란20 mg/d)치료;대조조(77례)단급항정신병약치료;량조우입조시、2주말、4주말분별평정억욱자평량표(SDS)화초필자평량표(SAS),이부반응량표(TESS)평정기안전성,연후진행비교.결과 량조적SDS화SAS총분재치료후균현저하강(P<0.05혹<0.01);연구조2주말화4주말적료효현저우우대조조(P<0.05혹<0.01);량조적불량반응비교차이무통계학의의(P>0.05).결론 항억욱약서태보란대정신분렬증후억욱유보조치료작용,불량반응경미.
Objective To explore the adjunct effects and safety of the anti - depression drug citalopram in treating post - schizophrenia depression symptoms. Methods Patients with post - schizo-phrenia anxiety and depression symptoms of CCMD - 3 were divided into two groups by random. The study group (n = 78) were treated with the combination with antipsychotics and anti - depression drug (citalo-pram 20 mg/d). The control group (n = 77) were treated only with antipsychotics respectively without added to citalopram. The scales of self - rating depression scale (SDS) and self - rating anxiety scale (SAS), and clinical effects were evaluated before treatment, after 2 weeks and after 4 weeks of treatment. The treatment emergent symptom scale (TESS) was checked to show side - effects. Results The total scores of SDS and SAS of two groups showed significantly lower after treatment (P < 0. 05 or < 0. 01). The 2 weeks' and 4 weeks' curative effects of the study group showed significantly better than those of the contol group (P <0. 05 or <0. 01). The side -effects showed no significant difference between the two groups (P > 0. 05). Conclusions There are adjunct effects of the anti - depression drug citalopram in treatment of post - schizophrenia depression symptoms. The side - effects are mild.
