中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2011年
7期
470-473
,共4页
叶国钦%Karin Everett%Noriko Taylor
葉國欽%Karin Everett%Noriko Taylor
협국흠%Karin Everett%Noriko Taylor
螺杆菌,幽门%口腔%胃%抗原,细菌%唾液%尿素%碳放射性同位素
螺桿菌,幽門%口腔%胃%抗原,細菌%唾液%尿素%碳放射性同位素
라간균,유문%구강%위%항원,세균%타액%뇨소%탄방사성동위소
Helicobacter pylori%Mouth%Stomach%Autigens,bacterial%Saliva%Urea%Carbon radioisotopes
目的 分析口腔和胃幽门螺杆菌(Hp)感染的检测结果,探讨口腔Hp感染与胃Hp感染的相关性,及口腔Hp感染对Hp根除治疗的影响.方法 采用唾液测定螺旋杆菌抗原技术(HPS)和13C/14C尿素呼气试验(UBT)同步检测的方法,对114例有上消化道症状的初诊患者(第1组),129例确诊为胃Hp感染经根除治疗后4周复查的患者(第2组)和33例无消化道症状的健康志愿者(第3组),进行口腔和胃Hp检测.结果 第1组、第2组和第3组HPS阳性检出率分别为77.19%、75.97%和81.82%,3组比较差异无统计学意义(χ2=0.47,P值均>0.05);UBT阳性检出率第1组(52.63%)比第2组(34.11%)和第3组(21.21%)高,第1组与第2组和第3组比较,差异有统计学意义(χ2=8.48和10.19,P均<0.05),第2组与第3组之间差异无统计学意义(χ2=2.03,P>0.05);在UBT阳性者中,HPS阳性检出率差异无统计学意义(3组分别为81.67%、88.64%和100%,χ2=2.25,P值均>0.05).结论 唾液中存在高Hp抗原检出现象,口腔可能是Hp在胃以外的"第二定居地".口服药物治疗对口腔Hp感染几乎无效,口腔Hp的存在可能是胃病发病和复发的一个重要和直接的原因.
目的 分析口腔和胃幽門螺桿菌(Hp)感染的檢測結果,探討口腔Hp感染與胃Hp感染的相關性,及口腔Hp感染對Hp根除治療的影響.方法 採用唾液測定螺鏇桿菌抗原技術(HPS)和13C/14C尿素呼氣試驗(UBT)同步檢測的方法,對114例有上消化道癥狀的初診患者(第1組),129例確診為胃Hp感染經根除治療後4週複查的患者(第2組)和33例無消化道癥狀的健康誌願者(第3組),進行口腔和胃Hp檢測.結果 第1組、第2組和第3組HPS暘性檢齣率分彆為77.19%、75.97%和81.82%,3組比較差異無統計學意義(χ2=0.47,P值均>0.05);UBT暘性檢齣率第1組(52.63%)比第2組(34.11%)和第3組(21.21%)高,第1組與第2組和第3組比較,差異有統計學意義(χ2=8.48和10.19,P均<0.05),第2組與第3組之間差異無統計學意義(χ2=2.03,P>0.05);在UBT暘性者中,HPS暘性檢齣率差異無統計學意義(3組分彆為81.67%、88.64%和100%,χ2=2.25,P值均>0.05).結論 唾液中存在高Hp抗原檢齣現象,口腔可能是Hp在胃以外的"第二定居地".口服藥物治療對口腔Hp感染幾乎無效,口腔Hp的存在可能是胃病髮病和複髮的一箇重要和直接的原因.
목적 분석구강화위유문라간균(Hp)감염적검측결과,탐토구강Hp감염여위Hp감염적상관성,급구강Hp감염대Hp근제치료적영향.방법 채용타액측정라선간균항원기술(HPS)화13C/14C뇨소호기시험(UBT)동보검측적방법,대114례유상소화도증상적초진환자(제1조),129례학진위위Hp감염경근제치료후4주복사적환자(제2조)화33례무소화도증상적건강지원자(제3조),진행구강화위Hp검측.결과 제1조、제2조화제3조HPS양성검출솔분별위77.19%、75.97%화81.82%,3조비교차이무통계학의의(χ2=0.47,P치균>0.05);UBT양성검출솔제1조(52.63%)비제2조(34.11%)화제3조(21.21%)고,제1조여제2조화제3조비교,차이유통계학의의(χ2=8.48화10.19,P균<0.05),제2조여제3조지간차이무통계학의의(χ2=2.03,P>0.05);재UBT양성자중,HPS양성검출솔차이무통계학의의(3조분별위81.67%、88.64%화100%,χ2=2.25,P치균>0.05).결론 타액중존재고Hp항원검출현상,구강가능시Hp재위이외적"제이정거지".구복약물치료대구강Hp감염궤호무효,구강Hp적존재가능시위병발병화복발적일개중요화직접적원인.
Objective To explore association between Helicobacter pylori (Hp) infection in oral cavity and gastric Hp infection through oral cavity and gastric Hp infection testing results analysis, and also to study the effect of Hp infection in oral cavity on Hp eradication treatment. Methods Through Hp saliva test (HPS) and 13C/14C urea breath test (UBT) method, the Hp in oral cavity and stomach were tested in 114 first-visit patients with upper gastrointestinal symptoms (group 1), 129 re-visiting patients who were diagnosed gastric Hp infection with eradication treatment for four weeks (group 2) and 33 volunteers without gastrointestinal symptoms. Results The positive rates of Hp infection by HPS method were 77.19%, 75.97% and 81.82% in group 1, group 2 and group 3 respectively. There was no significant difference between these three groups (χ2=0.47, P>0.05). The positive rate of Hp infection by UBT method in group 1 (52.63%) was higher than those of group 2 (34.11%) and group 3 (21.21%). Compared group 1 with group 2 or group 3, there was significant difference (χ2=8.848, 10.19, P<0.05). There was no significant difference between group 2 and 3 (χ2=2.03, P>0.05). In positive individuals of these three groups tested by UBT method, there was no significant difference of positive rate tested by HPS method (81.67%, 88.64% and 100% of three groups respectively, χ2=2.25, P>0.05). Conclusions The High detection of Hp antigen in saliva indicates that the oral cavity may be the "second settlement" of Hp beside stomach. The oral medicine haslittle effect on oral cavity Hp infection. The existence of oral Hp may be an important and direct factor of incidence and recurrent of gastric diseases.
