CAJ | 학술논문

目的探讨肱动脉内皮功能对老年冠心病患者的预测价值.方法测定98例冠心病患者及37例对照者肱动脉内皮依赖血管舒张功能(FMD)及非内皮依赖血管舒张功能(NMD),根据冠脉造影结果将患者分为冠脉病变＜50%,50%～75%,＞75%病变组和冠脉病变0、1、2、3支病变组,以比较老年冠心病患者冠脉病变程度、范围与肱动脉FMD及NMD的相关性,进一步探讨肱动脉内皮功能对老年冠心病患者的预测价值.结果冠心病组肱动脉FMD及NMD均较对照组显著降低;FMD及NMD减低均与冠状动脉病变相关(r=-0.54,-0.52,均P＜0.01),都与冠状动脉病变程度及范围呈弱相关性(P＜0.01);FMD、NMD均可作为评估冠状动脉病变的独立因素(OR值分别为0.81、0.82),FMD和NMD对诊断冠心病有意义(P＜0.05).结论血管内皮功能对老年冠心病患者有一定的预测价值.
목적 탐토굉동맥내피공능대노년관심병환자적예측개치.방법 측정98례관심병환자급37례대조자굉동맥내피의뢰혈관서장공능(FMD)급비내피의뢰혈관서장공능(NMD),근거관맥조영결과장환자분위관맥병변＜50%,50%～75%,＞75%병변조화관맥병변0、1、2、3지병변조,이비교노년관심병환자관맥병변정도、범위여굉동맥FMD급NMD적상관성,진일보탐토굉동맥내피공능대노년관심병환자적예측개치.결과 관심병조굉동맥FMD급NMD균교대조조현저강저;FMD급NMD감저균여관상동맥병변상관(r=-0.54,-0.52,균P＜0.01),도여관상동맥병변정도급범위정약상관성(P＜0.01);FMD、NMD균가작위평고관상동맥병변적독립인소(OR치분별위0.81、0.82),FMD화NMD대진단관심병유의의(P＜0.05).결론 혈관내피공능대노년관심병환자유일정적예측개치.
Objective To evaluate the value of endothelial function of brachial artery in predicting coronary artery disease in elderly patients. Methods Flow-mediated vasodilation (FMD)and nitroglycerin mediated dilation (NMD) were measured by high-frequency ultrasound in 98 patients with coronary artery disease and 37 controls. All the subjects were diagnosed by coronary arteriography. They were divided into coronary artery blockages ＜ 50% subgroup, 50%-75%subgroup, ＞75% subgroup or coronary blockages in 0, 1, 2, 3 branch (es) subgroups. The correlations between FMD or NMD and the pathological extent or branches of coronary artery were studied and the predictive value of FMD and NMD were analyzed with ROC curve. Results In coronary artery disease group, FMD and NMD were significantly decreased as compared with the control group. They were closely related with coronary artery disease (r= -0. 54, -0. 52, P＜0.01), and were weakly correlated with severity and range of coronary arterial lesion (P＜0. 01).With ROC curve analysis, FMD and NMD could be used to predict coronary artery disease.Conclusions Endothelial function can be used as an index to predict coronary artery disease.