CAJ | 학술논문

目的观察丙泊酚、瑞芬太尼、麻黄碱配合应用于胃镜检查时对循环、呼吸功能及麻醉效应的影响.方法患者120例,随机分为3组,A组单用丙泊酚;B组合用丙泊酚与瑞芬太尼;C组合用丙泊酚、瑞芬太尼及麻黄碱.观察患者药物用量、苏醒时睁眼、对答和自行离去时间、循环呼吸功能及不良反应.结果 B、C组丙泊酚用量比A组明显减少(P<0.05),呼之睁眼及自如对答时间比A组缩短(P<0.05),而C组患者白行离开时间要短于A、B两组(P<0.05);A、B两组患者用药后及呼之睁眼时MAP均较检查前明显降低、HR减慢(P<0.05),而C组患者检查前、用药后及呼之睁眼时MAP和HR均没有显著性差异(P>0.05);3组患者用药后及呼之睁眼时RR均减慢,SpO2降低(P<0.05);B、C组的注射部位疼痛及检查时肢体活动发生率比A组显著降低(P<0.05).结论瑞芬太尼伍用于丙泊酚可减少丙泊酚用量,降低注射部位疼痛及检查时肢体活动发生率,但并不减轻对循环呼吸的抑制作用;丙泊酚、瑞芬太尼、麻黄碱伍用则既能减少丙泊酚用量,循环功能亦较稳定,但不能减轻对呼吸的抑制作用.
목적 관찰병박분、서분태니、마황감배합응용우위경검사시대순배、호흡공능급마취효응적영향.방법 환자120례,수궤분위3조,A조단용병박분;B조합용병박분여서분태니;C조합용병박분、서분태니급마황감.관찰환자약물용량、소성시정안、대답화자행리거시간、순배호흡공능급불량반응.결과 B、C조병박분용량비A조명현감소(P<0.05),호지정안급자여대답시간비A조축단(P<0.05),이C조환자백행리개시간요단우A、B량조(P<0.05);A、B량조환자용약후급호지정안시MAP균교검사전명현강저、HR감만(P<0.05),이C조환자검사전、용약후급호지정안시MAP화HR균몰유현저성차이(P>0.05);3조환자용약후급호지정안시RR균감만,SpO2강저(P<0.05);B、C조적주사부위동통급검사시지체활동발생솔비A조현저강저(P<0.05).결론 서분태니오용우병박분가감소병박분용량,강저주사부위동통급검사시지체활동발생솔,단병불감경대순배호흡적억제작용;병박분、서분태니、마황감오용칙기능감소병박분용량,순배공능역교은정,단불능감경대호흡적억제작용.
Objective To observe the effect of propofol,remifintanil,ephedrine to circulation-breath function and the effect being anaesthetized in gastroscopy.Methods 120 patients were divided randomly into group A(propofol only),B(propofol,and,remifintanil)and C(propofol,remifintanil,and ephedrine).Medicine dosages,awake time,circulation-breath function and side effect were recorded.Results Propofol dosages were lower in group B and C than groupA(P<0.05),bur awake time was shorter than group A(P<0.05).Leaving-self time in group C was shorter than group A and B(P<0.05).Average arterial pressure and heart rate after anesthesia fallen significantly in group A and B(P<0.05),and no changing in group C(P>0.05).Breath rate and pulse oxygen saturation fallen signifieandy after anesthesia in three groups(P<0.05).The rate of inject location pain and limb moving were lower in group B and C than group A(P<0.05).Conclusion Remifentanil and propofol combination can reduce the propofol dosages,the incidence of injection site pain and physical activities,but not ease off circulation-brealh inhibitory action.However,that propofol,remifentanil,combined with ephedrine will reduce the amount of propofol,circulatory function more stable,but it cannot mitigate their inhibitory effect on respiration.