CAJ | 학술논문

肿瘤干细胞(CSC)具有自我更新及分化潜能,是肿瘤生长和转移的源泉,与化放疗抵抗密切相关,能否彻底根除CSC决定肿瘤治疗的成败.条件增殖腺病毒(CRAd)是一类仅在肿瘤细胞内特异增殖的新型病毒载体,可同时靶向肿瘤细胞和肿瘤干细胞,为彻底治愈肿瘤带来曙光.
종류간세포(CSC)구유자아경신급분화잠능,시종류생장화전이적원천,여화방료저항밀절상관,능부철저근제CSC결정종류치료적성패.조건증식선병독(CRAd)시일류부재종류세포내특이증식적신형병독재체,가동시파향종류세포화종류간세포,위철저치유종류대래서광.
Cancer stem cells (CSC) are capable of self-renewal and differentiation, properties that are critical to tumor growth, metastasis, and radioresistance. Eradication of CSC is the key to the success of cancer therapy. Conditionally replicative adenoviruses(CRAd) are a novel class of viral agents which selectively replicate in tumor cells but not in normal cells. CRAd can specifically target and eradicate CSC ,representing a promising cure for cancer.