CAJ | 학술논문

目的探讨奥扎格雷钠联合依达拉奉治疗急性脑梗死的疗效与安全性.方法将207例急性脑梗死患者随机分为观察组69例和对照A组69例、对照B组69例.观察组给予奥扎格雷钠联合依达拉奉治疗,对照A组给予奥扎格雷钠治疗,对照B组给予依达拉奉治疗.治疗前及治疗14 d后对3组患者的凝血指标及临床神经功能缺损程度评分(NDS)进行评定,比较疗效及安全性.结果治疗14 d后观察组的临床疗效明显优于对照A组和对照B组(P＜0.05),血小板、凝血指标均在正常范围内.结论应用奥扎格雷钠联合依达拉奉治疗急性脑梗死,两药具有起到叠加互助有效作用,且没有明显不良反应,值得基层医院大力推广应用.
목적 탐토오찰격뢰납연합의체랍봉치료급성뇌경사적료효여안전성.방법 장207례급성뇌경사환자수궤분위관찰조69례화대조A조69례、대조B조69례.관찰조급여오찰격뢰납연합의체랍봉치료,대조A조급여오찰격뢰납치료,대조B조급여의체랍봉치료.치료전급치료14 d후대3조환자적응혈지표급림상신경공능결손정도평분(NDS)진행평정,비교료효급안전성.결과치료14 d후관찰조적림상료효명현우우대조A조화대조B조(P＜0.05),혈소판、응혈지표균재정상범위내.결론 응용오찰격뢰납연합의체랍봉치료급성뇌경사,량약구유기도첩가호조유효작용,차몰유명현불량반응,치득기층의원대력추엄응용.
Objective To explore the efficacy and safety of sodium ozagrel combined with edaravone in the treatment of acute cerebral infarction.Methods 207 patinets were randomly assigned to receive sodium ozagrel combined with edaravone(69 patients,combination group),sodium ozagrel alone (69 patients,ozagrel group),or edaravone alone(69 patients,edaravone group). The coagulation indice and Neuropathy Disability Score(NDS)were assessed before and 14 days after treatment in the three groups;and the efficacy and safety were compared.Results After a 14day therapy,the efficacy in the combination group was obviously superior to that in ozagrel group or in edaravone group(P＜0.05).Platelet levels and coagulation indice were within the normal range.Conclusions Sodium ozagrel combined with edaravone has a synergistic effect in the treatment of acute cerebral infarction.The combination therapy has no obvious adverse reactions and is worth popularizing.