国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
4期
326-328
,共3页
李思佳%申超%徐丽丹%计薇%高旭
李思佳%申超%徐麗丹%計薇%高旭
리사가%신초%서려단%계미%고욱
川崎病%肿瘤坏死因子-α%基因多态性%荟萃分析
川崎病%腫瘤壞死因子-α%基因多態性%薈萃分析
천기병%종류배사인자-α%기인다태성%회췌분석
Kawasaki disease%Tumor necrosis factor-alpha%Polymorphism%Meta-analysis
目的 用荟萃(Meta)分析的方法研究肿瘤坏死因子α(TNF-α)基因启动子区多态位点(-308 G/A)与川崎病(KD)遗传易感性的关系.方法 收集Medline和EMBASE数据库中关于TNF-α-308 G/A与KD遗传易感性的相关文献,对其进行Meta分析.结果 经数据库检索,有4篇文献纳入本研究.对等位基因和基因型频率进行分析,结果显示TNF-α-308 G/A等位基因A的频率与川崎病遗传易感性无显著相关( OR =0.836,95％CI =0.347-2.012).基因型频率与川崎病遗传易感性无显著相关(Aavs.GG,OR=0.817,95％ CI=0.292-2.284；Aavs.GA,OR=0.980,95％ CI=0.300-3.206;AA +GA vs.GG,OR=0.840,95％CI =0.356-1.981;AA+GG vs.AA,OR =0.884,95％CI=0.636-1.227).结论 TNF-α-308 G/A位点基因多态性与川崎病遗传易感性无显著相关,仍需扩大研究样本量进行分析.
目的 用薈萃(Meta)分析的方法研究腫瘤壞死因子α(TNF-α)基因啟動子區多態位點(-308 G/A)與川崎病(KD)遺傳易感性的關繫.方法 收集Medline和EMBASE數據庫中關于TNF-α-308 G/A與KD遺傳易感性的相關文獻,對其進行Meta分析.結果 經數據庫檢索,有4篇文獻納入本研究.對等位基因和基因型頻率進行分析,結果顯示TNF-α-308 G/A等位基因A的頻率與川崎病遺傳易感性無顯著相關( OR =0.836,95％CI =0.347-2.012).基因型頻率與川崎病遺傳易感性無顯著相關(Aavs.GG,OR=0.817,95％ CI=0.292-2.284；Aavs.GA,OR=0.980,95％ CI=0.300-3.206;AA +GA vs.GG,OR=0.840,95％CI =0.356-1.981;AA+GG vs.AA,OR =0.884,95％CI=0.636-1.227).結論 TNF-α-308 G/A位點基因多態性與川崎病遺傳易感性無顯著相關,仍需擴大研究樣本量進行分析.
목적 용회췌(Meta)분석적방법연구종류배사인자α(TNF-α)기인계동자구다태위점(-308 G/A)여천기병(KD)유전역감성적관계.방법 수집Medline화EMBASE수거고중관우TNF-α-308 G/A여KD유전역감성적상관문헌,대기진행Meta분석.결과 경수거고검색,유4편문헌납입본연구.대등위기인화기인형빈솔진행분석,결과현시TNF-α-308 G/A등위기인A적빈솔여천기병유전역감성무현저상관( OR =0.836,95％CI =0.347-2.012).기인형빈솔여천기병유전역감성무현저상관(Aavs.GG,OR=0.817,95％ CI=0.292-2.284；Aavs.GA,OR=0.980,95％ CI=0.300-3.206;AA +GA vs.GG,OR=0.840,95％CI =0.356-1.981;AA+GG vs.AA,OR =0.884,95％CI=0.636-1.227).결론 TNF-α-308 G/A위점기인다태성여천기병유전역감성무현저상관,잉수확대연구양본량진행분석.
Objective To determine the relationship between tumor necrosis factor-alpha (TNF-α)308G/A and Kawasaki disease susceptibility by the method of Meta-analysis.Methods All related literatures about TNF-o-308 G/A and Kawasaki disease had been collected through MEDLINE and EMBASE database,then the data were synthesized and analyzed by Meta-analysis.Results Four literatures about TNF-α-308 G/Aand Kawasaki disease were included in the study.Gene effect was assessed using per-allele and per-genotype approaches.The pooled odds ratio of A versus G was 0.836,95％ CI =0.347-2.012.The results of genotype effects indicated that the genotype of TNFA -308 G/A was not a risk factor for KD,AA vs.GG,OR =0.817,95％GI =0.292-2.284;AA vs.GA,OR =0.980,95％CI =0.300-3.206;AA +GA vs.GG,OR =0.840,95％Cl =0.356-1.981 ;AA + GG vs.AA,OR =0.884,95％ CI =0.636-1.227.Conclusion The results indicated that TNF-α-308 G/A was not associated with Kawasaki disease susceptibility.An updated Meta-analysis is needed if more studies are published.
