CAJ | 학술논문

近年研究发现四环素类药物具有非抗菌性质，在治疗骨代谢疾病，抗肿瘤等方面很好的临床应用前景。本文主要综述了四环素类药物抑制基质金属蛋白酶、干预细胞因子的产生、抗氧自由基等的非抗菌作用机制，以及治疗牙周炎、骨关节炎、糖尿病、骨质疏松症、抗肿瘤、胸腔积液等的非抗菌临床应用。
근년연구발현사배소류약물구유비항균성질，재치료골대사질병，항종류등방면흔호적림상응용전경。본문주요종술료사배소류약물억제기질금속단백매、간예세포인자적산생、항양자유기등적비항균작용궤제，이급치료아주염、골관절염、당뇨병、골질소송증、항종류、흉강적액등적비항균림상응용。
Recent studies found that tetracyclines have non - antibiotic property, and tetracyclines will be more promising in the treatment of diseases in bone metabolism, antitumor, etc. This article reviews the non - antibiotic mechanism and non - antibiotic use of tetracyclines, mainly including matrix metalloproteinases, intervene the production of the cytokine, eactive oxygen radicals and treatment periodontitis, osteoarthritis, diabetes, osteoporosis, antitumor, pleural effusion and so on.