CAJ | 학술논문

在药物研究中用以进行超分子包合研究的主体有冠醚、环糊精、杯芳烃及瓜环等，它们均具有穴状结构，能通过非共价键与离子及中性分子形成超分子，可以提高药物的稳定性。本文重点介绍了这几种主要的超分子包合主体在药物研发中的应用研究进展，并对超分子包合技术在新药研制中的应用前景进行了展望。
재약물연구중용이진행초분자포합연구적주체유관미、배호정、배방경급과배등，타문균구유혈상결구，능통과비공개건여리자급중성분자형성초분자，가이제고약물적은정성。본문중점개소료저궤충주요적초분자포합주체재약물연발중적응용연구진전，병대초분자포합기술재신약연제중적응용전경진행료전망。
In pharmaceutical research,the supramolecular inclusion hosts include crown ether, cyclodextrin, calixarene and cucurbituril. They all have cavity structure and can form supermolecules with other ions and neutral molecules by the noncovalent bonds,which can improve medical stability. This paper surveys application advances of these supramolecular hosts in the pharmaceutical development. It also presents the application prospect of supramolecular inclusion technique in new medicine development.