中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
5期
489-491
,共3页
原发性高血压%肥胖%转化生产因子β_1%肾损害
原髮性高血壓%肥胖%轉化生產因子β_1%腎損害
원발성고혈압%비반%전화생산인자β_1%신손해
Essential hypertension%Obesity%Transforming growth factor β_1%Renal damage
目的 评估肥胖对肾功能的影响以及原发性高血压患者转化生长因子(TGF-β_1)水平和肥胖之间的潜在关系.方法 研究对象包括70例新诊断的高血压患者(高血压组)和30名正常对照者(对照组).检测两组受检者的血糖、血肌酐、血尿酸、血脂和TGF-β_1,并且收集24 h尿样,测定24 h尿微量清蛋白,计算肌酐清除率(CCr).结果 高血压组患者TGF-β1水平与对照组比较差异有统计学意义[(563.7±72.3)pg/ml vs.(451.3±71.6) pg/ml,P<0.01],而高血压组患者的CCr与对照组比较显著降低,差异有统计学意义[(99.1 ± 26.3)ml·min~(-1)·1.73 m~(-2) vs.(115.2 ± 23.1)ml·min~(-1)·1.73 m~(-2),P<0.01].高血压患者中肥胖组与非肥胖组的血清TGF-β_1水平[(593.7±67.9)pg/ml vs.(533.9 ±68.3)pg/ml]和CCr[(113.2±30.3)ml·min~(-1)·1.73 m~(-2) vs.(92.9±27.5) ml·min~(-1)·1.73 m~(-2)]以及尿微量清蛋白[(56.8±61.8)mg/24 h vs.(15.5 ± 11.6)mg/24 h]间差异均有统计学意义(P<0.05).高血压患者的TGF-β_1水平与体质指数呈正相关(r=0.359,P<0.05),与CCr亦呈正相关(r=0.278,P<0.05).结论 原发性高血压肥胖患者的CCr、UAE和血尿酸水平高于非肥胖患者;另外,原发性高血压患者的TGF-β_1水平与体质指数、CCr呈正相关.
目的 評估肥胖對腎功能的影響以及原髮性高血壓患者轉化生長因子(TGF-β_1)水平和肥胖之間的潛在關繫.方法 研究對象包括70例新診斷的高血壓患者(高血壓組)和30名正常對照者(對照組).檢測兩組受檢者的血糖、血肌酐、血尿痠、血脂和TGF-β_1,併且收集24 h尿樣,測定24 h尿微量清蛋白,計算肌酐清除率(CCr).結果 高血壓組患者TGF-β1水平與對照組比較差異有統計學意義[(563.7±72.3)pg/ml vs.(451.3±71.6) pg/ml,P<0.01],而高血壓組患者的CCr與對照組比較顯著降低,差異有統計學意義[(99.1 ± 26.3)ml·min~(-1)·1.73 m~(-2) vs.(115.2 ± 23.1)ml·min~(-1)·1.73 m~(-2),P<0.01].高血壓患者中肥胖組與非肥胖組的血清TGF-β_1水平[(593.7±67.9)pg/ml vs.(533.9 ±68.3)pg/ml]和CCr[(113.2±30.3)ml·min~(-1)·1.73 m~(-2) vs.(92.9±27.5) ml·min~(-1)·1.73 m~(-2)]以及尿微量清蛋白[(56.8±61.8)mg/24 h vs.(15.5 ± 11.6)mg/24 h]間差異均有統計學意義(P<0.05).高血壓患者的TGF-β_1水平與體質指數呈正相關(r=0.359,P<0.05),與CCr亦呈正相關(r=0.278,P<0.05).結論 原髮性高血壓肥胖患者的CCr、UAE和血尿痠水平高于非肥胖患者;另外,原髮性高血壓患者的TGF-β_1水平與體質指數、CCr呈正相關.
목적 평고비반대신공능적영향이급원발성고혈압환자전화생장인자(TGF-β_1)수평화비반지간적잠재관계.방법 연구대상포괄70례신진단적고혈압환자(고혈압조)화30명정상대조자(대조조).검측량조수검자적혈당、혈기항、혈뇨산、혈지화TGF-β_1,병차수집24 h뇨양,측정24 h뇨미량청단백,계산기항청제솔(CCr).결과 고혈압조환자TGF-β1수평여대조조비교차이유통계학의의[(563.7±72.3)pg/ml vs.(451.3±71.6) pg/ml,P<0.01],이고혈압조환자적CCr여대조조비교현저강저,차이유통계학의의[(99.1 ± 26.3)ml·min~(-1)·1.73 m~(-2) vs.(115.2 ± 23.1)ml·min~(-1)·1.73 m~(-2),P<0.01].고혈압환자중비반조여비비반조적혈청TGF-β_1수평[(593.7±67.9)pg/ml vs.(533.9 ±68.3)pg/ml]화CCr[(113.2±30.3)ml·min~(-1)·1.73 m~(-2) vs.(92.9±27.5) ml·min~(-1)·1.73 m~(-2)]이급뇨미량청단백[(56.8±61.8)mg/24 h vs.(15.5 ± 11.6)mg/24 h]간차이균유통계학의의(P<0.05).고혈압환자적TGF-β_1수평여체질지수정정상관(r=0.359,P<0.05),여CCr역정정상관(r=0.278,P<0.05).결론 원발성고혈압비반환자적CCr、UAE화혈뇨산수평고우비비반환자;령외,원발성고혈압환자적TGF-β_1수평여체질지수、CCr정정상관.
Objective To evaluate the effect of obesity on renal functions and the possible relationship between transforming growth factorβ_1 (TGF-β_1) and obesity in hypertensive patients.Methods Seventy newly diagnosed hypertensive patients and 30 normal people as controls were enrolled.The levels of glucose,creatinine,uric acid,lipids,and TGF-β_1,were measured for the subject in both group.A 24-hour urine sample was also obtained so as to calculate creatinine clearance rate (CCr) and urinary albumin excretion(UEA).Results TGF-β_1 level was significant higher in the hypertensive patients than in controls[(563.7±72.3)pg/ml vs (451.3±71.6) pg/ml](P<0.01),but CCr level was significant lower[(99.1 ± 26.3) ml·min~(-1)·1.73 m~(-2) vs (115.2±23.1)ml·min~(-1)·1.73 m~(-2)](P<0.01).The levels of TGF-β_1[(593.7±67.9) pg/ml vs (533.9 ±68.3)pg/ml,P<0.01],CCr(113.2±30.3)ml·min~(-1)·1.73 m~(-2) vs (92.9±27.5)ml·min~(-1)·1.73 m~(-2),P<0.01,and UAE[(56.8±61.8)mg/24 h vs (15.5 ±11.6)mg/24 h,P<0.05]were significantly higher in the patients with hypertension and obesity than in the patients with hypertension with no obesity.The TGF-β_1 level was correlated with body mass index(r=0.359,P<0.05),and CCr(r=0.278,P<0.05) in the hypertension patients.Conclusion The increased body mass index may be associated with increased levels of CCr,UAE,and TGF-β_1 in essential hypertension patients.In addition,TGF-β_1 is positively correlated with body mass index and CCr level in patients with essential hypertension.
